AI Article Synopsis
- Cyclic voltammetry tests were conducted on DNA probes linked to a ferrocene/isoquinoline conjugate using gold electrodes at different scan rates.
- The results showed that mismatched DNA duplexes have more bending flexibility than fully matched ones, which was indicated by the currents observed.
- This approach enabled the precise detection of various naturally occurring single-nucleotide polymorphisms by adjusting the pulse potential in square-wave voltammetry.
Article Abstract
Cyclic voltammetry was performed at various scan rates for the duplexes from ferrocene/isoquinoline conjugate-connected DNA probes on gold electrodes. The relationship between the observed currents and the scan rates disclosed the enhanced bending elasticity of the mismatched duplexes compared with the fully matched duplexes. The difference of the dynamics was easily detected through the currents from the conjugate by adjusting the pulse potential frequency in square-wave voltammetry. By using the present strategy, we succeeded in accurately detecting various naturally occurring single-nucleotide polymorphisms.
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| http://dx.doi.org/10.1002/chem.200802729 | DOI Listing |
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