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Purpose: This study has evaluated the effects of immobilization versus intermittent active motion on cartilage and on antibiotic efficacy in a rabbit septic arthritis model.
Methods: Rabbits were infected and assigned to one of four groups: group 1, no treatment without immobilization (allowing intermittent active motion); group 2, cast; group 3, oxacillin without immobilization; group 4, oxacillin and cast. Animals were sacrificed 21 days later. Bacterial counts and lateral radiograms were performed. A radiological score was calculated.
Results: Immobilization had no effect on oxacillin efficacy and a deleterious effect on the radiological score.
Conclusion: Intermittent active motion has allowed a better cartilage healing during the treatment of septic arthritis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656873 | PMC |
| http://dx.doi.org/10.1007/s11832-008-0128-7 | DOI Listing |
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