Synthesis of spiroacetal-nucleosides as privileged natural product-like scaffolds.

Org Biomol Chem

Department of Chemistry, The University of Auckland, 23 Symonds St, Auckland, New Zealand.

Published: April 2009

The elaboration of a 6,6-spiroacetal scaffold to incorporate a nucleoside unit at the anomeric position is described. The novel spiroacetal-nucleoside hybrids were generated via nucleosidation of acetoxy-spiroacetal with a series of silylated nucleobases under Vorbrüggen conditions.

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Source
http://dx.doi.org/10.1039/b818314gDOI Listing

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