Objectives: To determine oncology patients' pattern and rationale of complementary and alternative medicine (CAM) use, and canvass their views on the relative merits of allopathic and alternative medicine.
Design: Observational study of opinions from a cohort of patients using self-completion questionnaires.
Setting: Oncology departments of two UK teaching hospitals.
Participants: Voluntary participation of 200 oncology patients attending clinic.
Main Findings: Twenty-two percent of patients used CAM, with a preponderance towards younger, female patients. The commonest reasons for CAM use is to make the patient feel better and to help with their cancer. However, patients seldom believe there is more evidence for CAM or that CAM will cure them, indeed often noticing no benefits from the treatment. CAM users do not resort to complementary medicine due to dissatisfaction with their doctor but instead have considerable trust in their physicians. Only a minority believes their doctor knows about their CAM use.
Conclusion: CAM use by oncology patients in the UK is less common than that reported elsewhere. Although patients try CAM in the hope that it will help with their treatment, they are realistic about its likely benefits. It uptake is not as an indication of lack of faith in doctors, yet physicians are frequently unaware of use. Therefore, the medical profession should not feel threatened by patients resorting to CAM but instead focus on understanding the reasons behind it.
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http://dx.doi.org/10.1093/qjmed/hcp013 | DOI Listing |
BMC Musculoskelet Disord
January 2025
Physiotherapy Research Unit, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Background: Alterations in spatiotemporal parameters during walking modify and limit movement capacity in children with obesity. This study aimed to describe and compare the alterations in spatiotemporal parameters in schoolchildren according to body weight during all phases of walking.
Methods: We carried out a cross-sectional study of 94 schoolchildren aged 6 to 12 years and divided them into three study groups (normal weight, overweight, and obesity).
Sci Rep
January 2025
Department of Pediatric Dentistry Faculty of Dental Medicine, University of Damascus, Damascus, Syria.
This in vitro study aims to evaluate various surface treatments on the shear bond strength and failure mode of CAD/CAM PMMA teeth to the heat-polymerized acrylic denture base. The study sample consisted of 100 teeth that were divided equally into five groups: Group 1: denture artificial teeth (control), Group 2: PMMA teeth without surface treatment, Group 3: PMMA teeth with MMA etching, Group 4: PMMA teeth with sandblasting (aluminum oxide particles), and Group 5: PMMA teeth with perpendicular grooves. The shear bond strength test was performed using a universal testing machine and the failure mode was recorded.
View Article and Find Full Text PDFNat Commun
January 2025
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, UK.
ATR plays key roles in cellular responses to DNA damage and replication stress, a pervasive feature of cancer cells. ATR inhibitors (ATRi) are in clinical development for treating various cancers, including those with high replication stress, such as is elicited by ARID1A deficiency, but the cellular mechanisms that determine ATRi efficacy in such backgrounds are unclear. Here, we have conducted unbiased genome-scale CRISPR screens in ARID1A-deficient and proficient cells treated with ATRi.
View Article and Find Full Text PDFNat Commun
January 2025
MRC Cognition and Brain Sciences Unit, University of Cambridge, Cambridge, UK.
Structural brain organization in infancy is associated with later cognitive, behavioral, and educational outcomes. Due to practical limitations, such as technological advancements and data availability of fetal MRI, there is still much we do not know about the early emergence of topological organization. We combine the developing Human Connectome Project's large infant dataset with generative network modeling to simulate the emergence of network organization over early development.
View Article and Find Full Text PDFJ Dent
January 2025
Senior Research and Teaching Assistant, Clinic of Reconstructive Dentistry, Center for Dental Medicine, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland. Electronic address:
Objectives: A new abutment-free implant connection allows for direct screwing of FDPs on implants to avoid complications caused by cement rests or screw loosening, which may affect to screw torque and load distribution. The objective of this study was to test the initial (Fi) and final failure (Ff) loads and torque changes of abutment-free monolithic zirconia CAD-CAM fixed dental prostheses (FDPs) compared to titanium FDPs on different abutment designs.
Methods: Three-unit screw-retained FDPs (n=50) on two implants (n=100) were divided into groups (n=10) based on the implant-abutment connection and material of the supra-structure: (1) abutment-free monolithic CAD-CAM zirconia FDP (Abut-free-Zr), (2) abutment-free veneered titanium FDPs (Abut-free-Ti), (3) monolithic zirconia FDPs with titanium base abutments (Zr-Ti-Base), (4) monolithic zirconia FDPs on multi-unit abutments (Zr-MU), (5) veneered titanium FDP on multi-unit abutments (Ti-MU).
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