AI Article Synopsis
- A synthetic approach was used to investigate a CXCR3 pocket that can fit polycycloaliphatics.
- The research findings indicate that the tricyclic 2-adamantane and bicyclic (iso)bornyl structures are effectively recognized by the CXCR3 receptor.
- This study enhances understanding of how specific molecular shapes interact with CXCR3, which could have implications in drug development.
Article Abstract
A CXCR3 pocket capable of accommodating polycycloaliphatics was explored using a modular synthetic strategy. The systematic studies reveal that the tricyclic 2-adamantane and bicyclic (iso)bornyl group are efficiently recognized by CXCR3.
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| http://dx.doi.org/10.1016/j.bmcl.2009.02.093 | DOI Listing |
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