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Does mobilization for autologous stem cell transplantation damage stromal layer formation? | LitMetric

AI Article Synopsis

  • Autologous hematopoietic stem cell transplantation (HSCT) effectively treats blood cancers, but some patients struggle to mobilize hematopoietic stem cells (HSCs).
  • The study examined the formation and velocity of the stromal layer in bone marrow cultures from patients and healthy donors before and after HSC mobilization, revealing differences in the mobilization process.
  • Results indicated that while patients had similar stromal layer formation pre- and post-mobilization, healthy controls showed a significant decrease post-mobilization, suggesting that control HSCs might respond better to mobilization stimuli than those from patients.

Article Abstract

Autologous hematopoietic stem cell transplantation (HSCT) has proved efficient to treat hematological malignancies. However, some patients fail to mobilize HSCs. It is known that the microenvironment may undergo damage after allogeneic HSCT. However little is known about how chemotherapy and growth factors contribute to this damage. We studied the stromal layer formation (SLF) and velocity before and after HSC mobilization, through long-term bone marrow culture from 22 patients and 10 healthy donors. Patients' SLF was similar at pre- (12/22) and post-mobilization (9/20), however for controls this occurred more at pre-mobilization (9/10; p=0.03). SLF velocity was higher at pre than post-mobilization in both groups. Leukemias and multiple myeloma showed faster growth of SLF than lymphomas at post-mobilization, the latter being similar to controls. These findings could be explained by less uncommitted HSC in controls than patients at post-mobilization. Control HSCs may migrate more in response to mobilization, resulting in a reduced population by those cells.

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Source
http://dx.doi.org/10.1179/102453309X385232DOI Listing

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