A patient with a clonal infection of Burkholderia pseudomallei had subpopulations with ceftazidime and amoxicillin-clavulanate susceptibilities that differed among the clinical specimens. Resistance was associated with a novel Cys69Tyr substitution in the Ambler class A beta-lactamase. Susceptibility testing of multiple colony variants from different sites should be performed for patients with culture-confirmed melioidosis.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2681875 | PMC |
| http://dx.doi.org/10.1128/JCM.01657-08 | DOI Listing |
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