We report a rare case of a thoracic intramedullary subependymoma in a 37-year-old woman. The patient developed a monoparesis of the right leg after a subtotal resection of the tumor. During the 30 months of follow-up the neurological deficit improved and the patient remained symptom free without progression of the remnant tumor. A complete resection of the tumor is usually curative with improved function. However, aggressive surgery may cause either worsening of an existing deficit or the development of new deficits. In patients with poor delineation between the tumor and the spinal cord, subtotal removal and close follow-up should be considered.
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http://dx.doi.org/10.1016/j.jocn.2008.09.008 | DOI Listing |
J Neurooncol
February 2025
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 119 South 4th Ring West Road, Fengtai District, Beijing, 100070, P.R. China.
Purpose: This study analyzed spinal subependymoma (SP-SE) cases to evaluate treatment outcomes and identify factors influencing patient outcomes.
Method: Clinical data from our institution, along with relevant literature, were reviewed and summarized. Univariate and multivariate logistic regression analyses were conducted to assess factors impacting the prognosis of patients with primary spinal ependymomas.
Clin Neurol Neurosurg
February 2025
Department of Neurosurgery, National Center forNeurological Disorders, Neurosurgical Institute of Fudan University, Shanghai Clinical Medical Center of Neurosurgery, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Huashan Hospital, Fudan University, Shanghai 200040, China; Department of Neurosurgery, Neurosurgery Research Institute, Clinical Research and Translation Center, National Regional Medical Center, The First Affiliated Hospital, Fujian Medical University, Fuzhou 350035, China. Electronic address:
Background: Upper cervical spinal ependymomas (uCSE) is routinely identified as intramedullary ependymomas located from the oblongata medulla to C4 level. Our study aimed to report the outcomes and treatment profiles of uCSE from our cohort of uCSE patients.
Methods: This retrospective observational study included 108 patients with upper cervical spinal ependymomas (uCSE) who underwent surgery at Huashan Hospital from 2008 to 2022.
Surg Neurol Int
July 2024
Department of Neurological Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Background: Ependymomas, rare glial brain tumors, account for <5% of all brain tumors. Interestingly, over 60% of ependymomas occur in the spinal cord of adults, including those originating from the filum terminale, while the rest are found within the brain. The World Health Organization (WHO) categorizes ependymomas into three grades: subependymomas and myxopapillary ependymomas ([MEPNs]; WHO grade I), classic ependymomas (WHO grade II), and anaplastic ependymomas (WHO grade III).
View Article and Find Full Text PDFSurg Neurol Int
January 2024
Department of Neurosurgery, University of California Los Angeles (UCLA), Los Angeles, California, United States.
Background: Chiari (type I) malformations are typically congenital. Occasionally, however, tonsillar herniation can arise secondary to cerebrospinal fluid leakage, posterior fossa or intraventricular mass lesions, or other etiologies. We present the first-ever case of an intramedullary subependymoma at the cervicomedullary junction associated with vertebral bone abnormalities and an acquired secondary Chiari malformation.
View Article and Find Full Text PDFObjective: Spinal intramedullary ependymomas (IEs) represent a well-defined tumor entity usually warranting resection. Factors that determine full long-term neurological recovery after resection are seldomly reported on in larger clinical series. In this study, the authors aimed to highlight the neurological outcome of patients with IEs after resection, with a focus on full neurological recovery, and to explore possible risk factors for the absence of neurological amelioration to an optimal function after surgical treatment.
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