General practitioners are often the first point of contact for patients with oral white lesions, which represent a wide spectrum of diagnoses of varying seriousness. Some clinical features are classical and others overlap between different diagnoses; they should be correlated with patient history, and sometimes other investigations, for diagnosis. Leukoplakia is a clinical term, and is a diagnosis of exclusion with no histopathological connotation. It has been redefined to describe a predominantly white lesion with premalignant potential. Patients with lesions that are potentially malignant should be referred to an oral medicine specialist or oral maxillofacial surgeon for systematic management.
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http://dx.doi.org/10.5694/j.1326-5377.2009.tb02395.x | DOI Listing |
JAMA Netw Open
January 2025
Department of Management, Policy, and Community Health, School of Public Health, The University of Texas Health Science Center, Houston.
Importance: COVID-19 vaccine hesitancy among Black women is a critical public health concern, potentially exacerbating existing health disparities and impacting community-wide vaccination efforts.
Objective: To explore the factors associated with COVID-19 vaccine hesitancy among Black women in the US and identify the specific concerns and experiences shaping hesitant attitudes toward vaccination.
Design, Setting, And Participants: Qualitative study using in-depth, semistructured interviews conducted virtually between June and November 2021.
Background: Apolipoprotein ε4 allele (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD) with females having higher risk than males. Compared with non-carriers, cognitively normal, middle-aged APOE4 carriers have lower cerebral blood flow (CBF) decades before clinical symptoms appear. Early intervention to protect CBF would be critical for APOE4 carriers to mitigate AD progression.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive cognitive decline. APOE-ε4 has been identified as the most prevalent genetic risk factor for the early onset of AD, while ABCA7-80 (rs115550680) has been shown to have a stronger effect size than the APOE-ε4 allele and is associated with the development of late-onset of AD among African Americans. Although the efficiency of executive functions declines with age, some basic attentional functions and preserved knowledge may help mitigate the effects of aging on working memory.
View Article and Find Full Text PDFBackground: The Southern Illinois University Longitudinal Cognitive Aging Study (SIU LCAS) is a community-based, longitudinal cohort study initiated in 1984. LCAS was initially designed to improve the sensitivity of neuropsychological testing to diagnose mild cognitive impairment (MCI) and dementia in individuals residing in central and southern Illinois.
Method: Participants are recruited from the community via newspaper advertisement, word-of-mouth, and community presentations.
Alzheimers Dement
December 2024
Boston University School of Public Health, Boston, MA, USA.
Background: Global health is increasingly burdened by oral diseases (ODs) affecting 3.9 billion people, and Alzheimer's disease with related dementias (AD/ADRD), impacting 46.8 million globally.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!