AI Article Synopsis
- HUCB has therapeutic potential for treating CNS damage, including neonatal hypoxic-ischemic brain injuries in rats.
- In a study, HUCB transplantation post-injury improved sensorimotor reflexes and showed neuroprotective effects in the brain.
- The findings suggest that HUCB may help protect striatal neurons and enhance recovery following neonatal brain damage.
Article Abstract
Human umbilical cord blood mononuclear cells (HUCB) have been shown to have a therapeutic role in different models of central nervous system (CNS) damage, including stroke. We evaluated the possible therapeutic potential of HUCB in P7 rats submitted to the Rice-Vannucci model of neonatal hypoxic-ischemic (HI) brain damage. Our results demonstrated that intraperitoneal transplantation of HUCB, 3 h after the HI insult, resulted in better performance in two developmental sensorimotor reflexes, in the first week after the injury. We also showed a neuroprotective effect in the striatum, and a decrease in the number of activated microglial cells in the cerebral cortex of treated animals. We suggest that HUCB transplantation might rescue striatal neurons from cell death after a neonatal HI injury resulting in better functional recovery.
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| http://dx.doi.org/10.1089/scd.2009.0049 | DOI Listing |
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