A novel synthetic approach for the formal total synthesis of N-methylmaysenine (1) has been developed. Key steps involve the Ti-mediated vinylogous Mukaiyama aldol reaction of chiral ketene silyl N,O-acetal with beta-dithiane-substituted aldehyde, an aldol condensation, and a ring-closing metathesis reaction.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1021/ol900384u | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development and Validation of the Self-Stigma Scale for Secondary Vocational Students (SSS-SVS).
Psychol Res Behav Manag
January 2025
Department of Psychology, Shaoxing University, Shaoxing, 312000, People's Republic of China.
Background: Stigma can not only threaten the self-identity of secondary vocational students, but also have negative effects on their mental health and behavior.
Objective: This study aimed to develop the Self-Stigma Scale for Secondary Vocational Students (SSS-SVS) and test its reliability and validity.
Patients And Methods: This study formed a scale based on the stigma conceptualization model and open questionnaire.
Schedule optimization for chemical library synthesis.
Digit Discov
December 2024
Department of Chemical Engineering, MIT Cambridge MA 02139 USA
Automated chemistry platforms hold the potential to enable large-scale organic synthesis campaigns, such as producing a library of compounds for biological evaluation. The efficiency of such platforms will depend on the schedule according to which the synthesis operations are executed. In this work, we study the scheduling problem for chemical library synthesis, where operations from interdependent synthetic routes are scheduled to minimize the makespan-the total duration of the synthesis campaign.
View Article and Find Full Text PDFRADAR - Radiomics on aSDH: predicting outcome with surface area.
Acta Neurochir (Wien)
January 2025
Department of Neurosurgery, University Hospital Leipzig, 04103, Leipzig, Germany.
Background: Acute subdural hematoma is a critical condition, leading to significant morbidity and mortality. Despite advancements in surgical techniques, a portion of patients only show limited clinical improvement post-evacuation. Surgical intervention decisions are critically important, as they can either improve or worsen a patient's condition.
View Article and Find Full Text PDFAssociations of fat, bone, and muscle indices with disease severity in patients with obstructive sleep apnea hypopnea syndrome.
Sleep Breath
January 2025
Department of Pulmonary and Critical Care Medicine, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, No.1 Da Hua Road, Dong Dan, Dongcheng District, Beijing, 100730, PR China.
Purpose: To investigate the relationship between obstructive sleep apnea hypopnea syndrome (OSAHS) severity and fat, bone, and muscle indices.
Methods: This study included 102 patients with OSAHS and retrospectively reviewed their physical examination data. All patients underwent polysomnography, body composition analysis, dual-energy X-ray absorptiometry, computed tomography (CT) and blood test.
Neck pain associated with headache attributed to rhinosinusitis: an observational study.
J Man Manip Ther
January 2025
Graduate Studies in Health & Rehabilitation Sciences, Des Moines University, Youngstown, OH, USA.
Background: Neck pain is common among people with headache, including migraines, tension headache, and cervicogenic headache. Neck pain has also been associated with self-reported sinus headache in individuals who were not formally diagnosed with headache attributed to rhinosinusitis (HAR). Neck pain, in individuals diagnosed with HAR according to the International Classification of Headache Disorders, has not been investigated.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!