Enantioenriched tetrasubstituted thiochromanes have been synthesized using a tandem Michael addition-Knoevenagel reaction between 2-mercaptobenzaldehydes and benzylidenemalonates with a 9-epi-aminoquinine thiourea derivative as the catalyst. Steric and electron effects were found to affect profoundly the enantioselectivity and diastereoselectivity of the reaction.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2350192 | PMC |
| http://dx.doi.org/10.1016/j.tetlet.2008.01.113 | DOI Listing |
Publication Analysis
Top Keywords
organocatalytic highly
4
highly enantioselective
4
enantioselective tandem
4
tandem michael-knoevenagel
4
michael-knoevenagel reaction
4
reaction synthesis
4
synthesis substituted
4
substituted thiochromanes
4
thiochromanes enantioenriched
4
enantioenriched tetrasubstituted
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!