Kraepelin proposed dementia praecox and manic-depressive illness as the two major psychotic disorders. This paradigm is still prevalent, but observations of overlapping boundaries between bipolar disorder and schizophrenia challenge this dichotomy. However, the concept of schizophrenia has been radically altered from the original Kraepelinian proposal. We defend the two psychoses positions, but suggest two flaws in the heuristic application: (1) overlapping features, such as psychotic symptoms, are not decisive in differential diagnosis; and (2) each disorder is a syndrome, not a disease entity. An alternative paradigm based on domains of pathology is more powerful for studies of etiology, pathophysiology, and therapeutic discovery.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2721021 | PMC |
| http://dx.doi.org/10.1038/npp.2009.32 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
[From Kraepelin to McGorry: Scientific Vision and Experiential Narrative around a Major Paradigmatic Shift].
Sante Ment Que
May 2022
Clinique Aufréry, Pin-Balma, France.
Objectives Until the early 1990s, a pessimistic view of psychotic disorders, based on the Kraepelinian perspective, prevailed. Early intervention then introduced a new paradigm, approaching psychosis as a more dynamic phenomenon, for which recovery is possible, provided an appropriate approach is used. As this paradigm has not penetrated all fields of psychiatry, professionals starting in early intervention sometimes experience a real culture shock, the objective of this article being to map its contours in order to facilitate this transition.
View Article and Find Full Text PDFDepression and Schizophrenia: Cause, Consequence, or Trans-diagnostic Issue?
Schizophr Bull
March 2017
Mental Health and Wellbeing, Warwick Medical School, University of Warwick, Coventry, UK.
The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognizing depression in schizophrenia bring.
View Article and Find Full Text PDFIntegrating Insults: Using Fault Tree Analysis to Guide Schizophrenia Research across Levels of Analysis.
Front Hum Neurosci
January 2016
Department of Biomedical Engineering, University of Minnesota Minneapolis, MN, USA.
The grand challenges of schizophrenia research are linking the causes of the disorder to its symptoms and finding ways to overcome those symptoms. We argue that the field will be unable to address these challenges within psychiatry's standard neo-Kraepelinian (DSM) perspective. At the same time the current corrective, based in molecular genetics and cognitive neuroscience, is also likely to flounder due to its neglect for psychiatry's syndromal structure.
View Article and Find Full Text PDFDifferential typology of delusions in major depression and schizophrenia. A critique to the unitary concept of 'psychosis'.
J Affect Disord
January 2015
Department of Mental Health and Pathological Addiction, AUSL Reggio Emilia - Reggio Emilia, Italy.
It is a current trend in psychiatry to discard the Kraepelinian dichotomy schizophrenia vs. manic-depressive illness and use the overinclusive label 'psychosis' to broadly indicate the whole spectrum of severe mental disorders. In this paper we show that the characteristics of psychotic symptoms vary across different diagnostic categories.
View Article and Find Full Text PDFIs it time to awaken Sleeping Beauty? European psychiatry has been sleeping since 1980.
Rev Psiquiatr Salud Ment
October 2016
University of Kentucky Mental Health Research Center, Eastern State Hospital, Lexington, KY, Estados Unidos; Psychiatry and Neurosciences Research Group (CTS-549), Institute of Neurosciences, University of Granada, Granada, España. Electronic address:
The Diagnostic and Statistical Manual of Mental Disorders (DSM-III), published in 1980, has led to a dead end, the DSM-V. Following the allegory of Sleeping Beauty, the DSM-III put European psychiatry to sleep; it now must wake up to create a 21st century psychiatric language for descriptive psychopathology and psychiatric nosology. Four topics are reviewed.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!