AI Article Synopsis
- The project aimed to create a method for using wireless video capsule endoscopy in preclinical research with pigs.
- Five female pigs were studied, and the capsule endoscopes recorded for a median of 492 minutes, reaching the cecum only once.
- The findings indicated that the small intestine's structure in pigs differs from humans, suggesting that this technique could aid future research on drug effects on the small bowel.
Article Abstract
The aim of this project was to develop a methodology to introduce wireless video capsule endoscopy in preclinical research. Five mature female pigs (Sus scrofa domestica) were selected for the study. Capsule endoscopes (the EndoCapsule system; Olympus) were introduced into the duodenum endoscopically in each of the animals. The life span of batteries (i.e., total time of endoscopy recording) was 487-540 min (median 492 min). The capsule endoscope reached the cecum during enteroscopy once (after 7 h 57 min), in the remaining cases, endoscopy recordings terminated in the distal or terminal ileum. All capsule enteroscopies found a normal pattern of the small intestine. The intestinal lumen is narrower, transverse folds are sparse or even absent, villi are wider but less prominent in pigs compared to humans. Capsule endoscopy in experimental pigs will be helpful for future trials on injury of different drugs and xenobiotics to the small bowel.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2822909 | PMC |
| http://dx.doi.org/10.1007/s10620-009-0779-3 | DOI Listing |
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