AI Article Synopsis
- The study focuses on the role of reticulocyte hemoglobin content (RET-Y) in assessing iron status among hemodialysis patients, particularly its effectiveness compared to conventional iron indices.
- Researchers analyzed data from 289 hemodialysis patients, categorizing them based on serum ferritin and transferrin saturation levels, and found that those with absolute iron deficiency had lower RET-Y values and mean corpuscular volume (MCV).
- The findings suggest that while RET-Y levels were similar to those of the normal population, low RET-Y levels were significant in patients with iron deficiency and EPO independence, indicating a strong correlation between RET-Y and serum albumin levels in chronic hemodialysis patients.
Article Abstract
Background: Iron deficiency is the most common factor associated with erythropoietin (EPO) hyporesponsiveness. Current iron indices are inadequate to demonstrate the status or utility of iron in erythropoiesis. The aims of this study are to investigate the value of the reticulocyte hemoglobin content, RET-Y, in hemodialysis (HD) patients and compare the levels with conventional iron indices.
Methods: HD patients (n = 289) were divided into 4 groups according to serum ferritin (cutoff value 100 ng/ml) and transferrin saturation (TSAT, cutoff value 20%). The RET-Y value, hemogram and biochemical data were determined and compared between groups. Factors associated with RET-Y were examined.
Results: The mean RET-Y value was 1,716 +/- 125 AU. Patients with absolute iron deficiency had lower RET-Y levels and mean corpuscular volume (MCV). Patients with functional iron deficiency had a lower reticulocyte production index and serum albumin levels. MCV, mean corpuscular hemoglobin concentration (MCHC) and albumin were independently correlated with the RET-Y level (all p < 0.001). EPO-independent patients had low iron indices and low RET-Y levels, but a higher reticulocyte production index and albumin levels were noted.
Conclusion: RET-Y levels in HD patients were close to that of the normal population. Low RET-Y levels were observed in patients with absolute iron deficiency and also in EPO-independent patients with low ferritin and low TSAT. There was a strong association between the serum albumin and RET-Y levels in chronic HD patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000209151 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Anemia in chronic renal disease: evaluation of inflammatory activity on erythropoiesis and iron metabolism in patients not submitted to dialysis treatment.
Clin Lab
October 2012
Department of Clinical Pathology, State University of Campinas, Sao Paulo, Brazil.
Background: Inflammatory activity is one of the factors involved in the physiopathology of anemia in patients with chronic kidney disease (CKD). The majority of studies on anemia, inflammation, and disturbances of iron metabolism have focused on patients in end-stage renal failure and dialysis therapy. However, anemia and inflammation are present in patients in previous stages of renal failure.
View Article and Find Full Text PDFRET-Y and RBC-Y in the diagnosis of iron deficiency associated with anaemia of inflammation.
Int J Lab Hematol
October 2010
Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia.
We evaluated the usefulness of RET-Y and RBC-Y in distinguishing functional iron deficiency from iron-deficiency anaemia (IDA) in patients with anaemia of inflammation (AI). Sixty healthy blood donors constituted the control group. We studied RET-Y and RBC-Y in 115 patients with hypochromic/microcytic anaemia.
View Article and Find Full Text PDFClinical interpretation of reticulocyte hemoglobin content, RET-Y, in chronic hemodialysis patients.
Nephron Clin Pract
July 2009
Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital, Kaohsiung Medical Center, 123 Ta-Pei Road, Niao-Sung Hsiang, Kaohsiung Hsien 833, Taiwan.
Article Synopsis
- The study focuses on the role of reticulocyte hemoglobin content (RET-Y) in assessing iron status among hemodialysis patients, particularly its effectiveness compared to conventional iron indices.
- Researchers analyzed data from 289 hemodialysis patients, categorizing them based on serum ferritin and transferrin saturation levels, and found that those with absolute iron deficiency had lower RET-Y values and mean corpuscular volume (MCV).
- The findings suggest that while RET-Y levels were similar to those of the normal population, low RET-Y levels were significant in patients with iron deficiency and EPO independence, indicating a strong correlation between RET-Y and serum albumin levels in chronic hemodialysis patients.
Ret-Y a measure of reticulocyte size: a sensitive indicator of iron deficiency anemia.
Clin Lab Haematol
December 2004
Department of Pathology, Johns Hopkins, University School of Medicine, Baltimore, MD 21231, USA.
In this study the size of reticulocytes was measured, reticulocyte-Y (Ret-Y), to distinguish iron deficiency anemia from the anemia of chronic disease using a Sysmex XE2100 cell counter. We evaluated this parameter prospectively in 100 patients seen for the evaluation of anemia. A clinical diagnosis of iron deficiency anemia or anemia of chronic disease was made on the basis of a complete blood count, examination of the peripheral smear, and serum ferritin along with a history and physical examination.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!