Long-term penicillamine therapy has been associated with alterations in dermal elastic tissue. Well-described associated dermatoses include pseudo-pseudoxanthoma elasticum, acquired cutis laxa, elastosis perforans serpiginosa, and anetoderma. Histologically, "lumpy-bumpy"" or "bramble-bush"" morphologic changes of elastic fibers in the dermis are characteristic. Previous reports of these findings in normal-appearing skin and internal organs suggest a systemic elastolytic process. Here we report an unusual case of penicillamine-induced elastosis affecting the mucosa of the lip with characteristic histologic features.
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2nd Department of Dermatology-Venereology, National Kapodistrian University of Athens, Attikon University Hospital, Athens, Greece.
Article Synopsis
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All India Institute of Medical Sciences, Department of Pathology. Bhubaneswar, Orissa, India.
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Dr. Muzamil Amin Chisti, MBC 46 Department of Dermatology,, King Faisal Specialist Hospital and Research Centre,, PO Box 3354, Riyadh 11211, Saudi Arabia, T: +966114424608, ORCID: http:// orcid.org/0000-0002-6877-2715.
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