A simple and solvent-free procedure to synthesize alpha,alpha'-bis(substituted benzylidene) cycloalkanones, catalyzed by copper(II) trifluoroacetate through crossed-aldol condensation of various aromatic aldehydes with cyclic ketones is reported. The reaction proceeded smoothly in good to excellent yields.
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Development of ruthenium complexes with S-donor ligands for application in synthesis, catalytic acceptorless alcohol dehydrogenation and crossed-aldol condensation.
Dalton Trans
June 2024
Department of Chemistry, Inorganic Chemistry Section, Jadavpur University, Kolkata - 700032, India.
The reaction of [Ru(dmso)Cl] with a potassium salt of four xanthate (RO-C(S)S; R = Me, Et, Pr and Bu) ligands (depicted as L; = 1-4) in hot methanol afforded a group of mixed-ligand complexes of type [Ru(L)(dmso)]. The crystal structures of all the four complexes have been determined, which show that the xanthate ligands are bound to the metal center forming four-membered chelates and dmso is coordinated through sulfur and they are mutually . The relative thermodynamic stability of this and the other possible -isomers of these complexes has been assessed with the help of DFT calculations, which have revealed that the -isomer is the more stable isomer.
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Biopolymers
May 2024
Department of Chemistry, Chungbuk National University, Cheongju, Chungbuk, Republic of Korea.
Conformational search and density functional theory calculations were performed to explore the preferences of helical structures for chiro-specific oligo-γ-peptides of 2-(aminomethyl)cyclopentanecarboxylic acid (γAmc) with a cyclopentyl constraint on the C-C bond in solution. The dimer and tetramer of γAmc (1) with homochiral (1S, 2S) configurations exhibited a strong preference for the 9-membered helix foldamer in solution, except for the tetramer in water. However, the oligomers of γAmc (1) longer than tetramer preferentially adopted a right-handed (P)-2.
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Angew Chem Int Ed Engl
April 2024
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo, 192-0397, Japan.
Article Synopsis
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Chromium-Catalyzed Cross-Coupling of Methyl Ketones with Cyclic Ketones toward the Selective Synthesis of β-Branched β,γ-Unsaturated Ketones.
Org Lett
January 2024
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, Assam, India.
Chromium-catalyzed cross-coupling of methyl ketones with cyclic ketones to β-branched β,γ-unsaturated ketones are reported. Interestingly, single-crossed aldol condensation products are formed, even in reactions in which a mixture of products is possible. The reaction is highly chemoselective and regioselective.
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Chemistry
March 2024
Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati, Assam, India, 781039.
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