The demand for expert neuropathologic intraoperative diagnoses often exceeds the available supply and geographic distribution of neuropathology centers. Telepathology has therefore been implemented in recent years to meet this demand. Herein, we draw on our experience with 4 generations of telepathology systems over the past 8 years to discuss the design, initiation and maintenance of an effective telepathology service for neuropathologists, including when to change systems. In addition to workflow efficiency, unique advantages of telepathology include integration into other informatics modalities, quality assurance/quality control (QA/QC) maintenance and the potential for visual data to be readily available to clinicians. Given the improvements in technology and the multiple uses of telepathology, this method for delivering patient care will undoubtedly continue to grow over time.
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http://dx.doi.org/10.1111/j.1750-3639.2009.00265.x | DOI Listing |
J Neurooncol
January 2025
Department of Neurosurgery, NYU Langone Health and NYU Grossman School of Medicine, 530 1st Avenue, Skirball Suite 8R, New York, NY, 10016, USA.
Unlabelled: QUESTIONS AND RECOMMENDATIONS FROM THE PRIOR VERSION OF THESE GUIDELINES WITHOUT CHANGE: TARGET POPULATION: Adult patients (age ≥ 18 years) who have suspected low-grade diffuse glioma.
Question: What are the optimal neuropathological techniques to diagnose low-grade diffuse glioma in the adult?
Recommendation: Level I Histopathological analysis of a representative surgical sample of the lesion should be used to provide the diagnosis of low-grade diffuse glioma. Level III Both frozen section and cytopathologic/smear evaluation should be used to aid the intra-operative assessment of low-grade diffuse glioma diagnosis.
Neurooncol Adv
October 2024
Department of Biomedical Engineering, Linköping University, Linköping, Sweden.
Background: Brain tumor needle biopsy interventions are inflicted with nondiagnostic or biased sampling in up to 25% and hemorrhage, including asymptomatic cases, in up to 60%. To identify diagnostic tissue and sites with increased microcirculation, intraoperative optical techniques have been suggested. The aim of this study was to investigate the clinical implications of in situ optical guidance in frameless navigated tumor biopsies.
View Article and Find Full Text PDFJ Alzheimers Dis
January 2025
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients, and cerebral small vessel disease (CSVD) has been suggested as a potential risk factor. This review examines the relationship between POCD and CSVD from epidemiological, pathophysiological, and clinical perspectives, while also considering the role of Alzheimer's disease (AD) pathology. We conducted a comprehensive literature search of major databases, supplemented by reference list checking, to ensure a thorough review of studies published between 2000 and 2023 on the relationship between POCD and CSVD.
View Article and Find Full Text PDFFree Neuropathol
January 2024
National Center of Pathology (NCP), Laboratoire national de santé (LNS), Dudelange, Luxembourg.
As in previous years, including 2023, a major focus in the neurooncological area of neuropathology was put on more precise and constantly faster diagnostic procedures, even reaching the level of ultra-fast intraoperative diagnostics based on methylation profiling. Neuropathological diagnostic precision and clinical follow-up treatment has been further increased by combining DNA methylation profiling with targeted panel sequencing. A few new, molecularly defined tumor subtypes have been proposed, among others, a glioneuronal tumor with alteration, kinase fusion and anaplastic features (in its abbreviated form named GTAKA) and the de novo replication repair deficient glioblastoma, IDH-wildtype both having either distinct prognostic or therapeutic implications.
View Article and Find Full Text PDFNeurooncol Adv
October 2024
Department of Neurosurgery, LMU University Hospital, Ludwig-Maximilians-University, Munich, Germany.
Tumors of astrocytic origin represent one of the most frequent entities among the overall rare group of spinal cord gliomas. Initial clinical symptoms are often unspecific, and sensorimotor signs localizing to the spinal cord occur with progressing tumor growth. On MRI, a hyperintense intrinsic spinal cord signal on T-weighted sequences with varying degrees of contrast enhancement raises suspicion for an infiltrative neoplasm.
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