Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2674986 | PMC |
| http://dx.doi.org/10.1113/jphysiol.2009.170027 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Phase Separation to Resolve Growth-Related Circuit Failures.
bioRxiv
November 2024
School of Biological and Health Systems Engineering, Arizona State University, Tempe, Arizona 85281, United States.
Fluctuations in host cell growth poses a significant challenge to synthetic gene circuits, often disrupting circuit function. Existing solutions typically rely on circuit redesign with alternative topologies or additional control elements, yet a broadly applicable approach remains elusive. Here, we introduce a new strategy based on liquid-liquid phase separation (LLPS) to stabilize circuit performance.
View Article and Find Full Text PDFThe Potential of Self-Activating Au(I) Complexes in Gold Catalysis.
Chemistry
August 2024
Department of Inorganic Chemistry, Instituto de Síntesis Química y Catálisis Homogénea (ISQCH), CSIC-Universidad de Zaragoza, C/Pedro Cerbuna 12, Zaragoza, 50009, Spain.
Gold catalysis has emerged as a groundbreaking field in synthetic chemistry, revolutionizing numerous organic transformations. Despite the significant achieved advancements, the mechanistic understanding behind many gold-catalyzed reactions remains elusive. This Concept article covers the so-called "self-activating" Au(I) complexes, sorting out their pivotal role in gold catalysis.
View Article and Find Full Text PDFRational design of pyrrolic-N dominated carbon material derived from aminated lignin for Zn-ion supercapacitors.
J Colloid Interface Sci
July 2023
Department of Chemical Engineering, University of New Brunswick, Fredericton, New Brunswick E3B5A3, Canada. Electronic address:
Developing highly efficient, sustainable carbon cathodes is essential for emerging Zn-ion hybrid supercapacitors (ZICs). Herein, lignin's novel chemical modification (amination) has been developed to produce high quantity pyrrolic-N moieties as active sites. Furthermore, chemically modified amine moieties in lignin are vital as a natural self-activating template to generate hierarchical porosity in the 2D (graphene-like) architecture with exceedingly high surface area (2926.
View Article and Find Full Text PDFA self-activating nanoized vascular disrupting agent for selective anti-tumor therapy.
Biomaterials
September 2022
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China; School of Applied Chemistry and Engineering, University of Sciences and Technology of China, Hefei, 230026, China.
Vascular disrupting agents (VDAs) have great potential in antitumor therapy, while the efficiency is limited by cardiovascular toxicity. In this study, a self-activating nanoized plinabulin (poly (-glutamic acid) grafted Azo-Plinabulin, AzoP-NP) was constructed. The AzoP-NPs can selectively be activated to an amino derivative of plinabulin (AmP) by intrinsic tumor hypoxia, disrupting tumor vessels and amplifying hypoxia, whilst be activated by self-amplified tumor hypoxia, then selectively inhibit tumor growth.
View Article and Find Full Text PDFMutational Analysis of a Highly Conserved PLSSMXP Sequence in the Small Subunit of γ-Glutamyltranspeptidase.
Biomolecules
September 2019
Department of Applied Chemistry, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, Taiwan.
Article Synopsis
- A conserved PLSSMXP sequence was identified in the small subunit of the γ-glutamyltranspeptidase (GGT) enzyme, indicating its potential role in the enzyme's function.
- Mutations through deletion and alanine-scanning showed that deletion mutants lost enzymatic activity, while most alanine replacements maintained similar activity to the wild-type enzyme.
- Structural analyses revealed that alterations in the microenvironment due to mutations affect both the self-activation and catalytic processes of GGT.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!