Alkyne-linked 2,2-disubstituted-indolin-3-one oligomers as extended beta-strand mimetics.

J Am Chem Soc

Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.

Published: April 2009

AI Article Synopsis

  • Researchers designed a new foldamer that mimics the structure of an extended beta-sheet using 2,2-disubstituted-indolin-3-one groups connected by an alkyne spacer.
  • The unique configuration features an intramolecular hydrogen bond that helps maintain a conformation similar to beta-strand side chain arrangements.
  • This innovative design could lead to the development of longer oligomers aimed at disrupting important protein-protein interactions relevant to disease treatment.

Article Abstract

The design, synthesis, and structural analysis of a new foldamer that mimics an extended beta-sheet are presented. The nonpeptidic mimetic is based on a series of 2,2-disubstituted-indolin-3-one groups linked through their 4,7-positions by an alkyne spacer. An intramolecular hydrogen bond between the carbonyl of one indolinone subunit and the proximal NH of another subunit imposes a conformation that mimics the side chain positioning on a beta-strand. X-ray crystallographic studies support the presence of this intramolecular hydrogen bond. The described approach allows extension of the scaffold to longer oligomers that will form the basis of new mimetics for the disruption of therapeutically relevant protein-protein interactions that rely on the contacts of side chain residues on two beta-strands.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2767320PMC
http://dx.doi.org/10.1021/ja809245tDOI Listing

Publication Analysis

Top Keywords

intramolecular hydrogen
8
hydrogen bond
8
side chain
8
alkyne-linked 22-disubstituted-indolin-3-one
4
22-disubstituted-indolin-3-one oligomers
4
oligomers extended
4
extended beta-strand
4
beta-strand mimetics
4
mimetics design
4
design synthesis
4

Similar Publications

In this work, a novel fluorescent probe (compound 2) based on the Intramolecular charge transfer (ICT) mechanism was designed and successfully applied to determine HS in human serum. Fluorophore 1,8-naphthalimide was chosen, while the azide group was the recognition group for HS determination. By introducing p-toluidine moiety on the imide part of the molecule, a donor-acceptor (D-A) conjugated system was formed.

View Article and Find Full Text PDF

Polyurethane Elastomers Strengthened by Pseudo[1]rotaxanes Based on Pillararenes.

Angew Chem Int Ed Engl

December 2024

Hangzhou Normal University, College of Material, Chemistry and Chemical Engineering, 2318 Yuhangtang Rd, 311121, Hangzhou, CHINA.

As a unique property of the interlocked structures, rotaxane allows for intramolecular motions between its wheel and axle components. Introduction of rotaxanes into polymers can endow them with distinctive macroscopic features and outstanding mechanical properties. Here, we prepare a copillar[5]arene with a hydroxyl and an amino-group on each end, which can spontaneously form a pseudo[1]rotaxane through intramolecular hydrogen bonds.

View Article and Find Full Text PDF

Photothermal-triggering shape memory polyurethane allows for precise and controllable shape transformation under remote light stimulation, making it highly desirable for applications in intelligent devices. This study develops a sustainable and high-performance lignin-based polyurethane (LPU) using a one-stone-two-birds strategy, wherein lignin serves as both a synthetic monomer and an internal photothermal agent. The incorporation of lignin significantly improved the mechanical properties of LPU, achieving a tensile strength of 42.

View Article and Find Full Text PDF

In this study, a tetradentate Schiff-base ligand (HL), synthesized by the condensation of ethylenediamine with 2-hydroxy-3-methoxy-5-methylbenzaldehyde, was reacted with either manganese salts or manganese salts in the presence of various pseudohalides in methanol. This reaction resulted in the formation of five mononuclear Mn complexes: [Mn(L)(HO)](NO)·1/2HO·1/2CHOH (), [Mn(L)(HO)](ClO)·HO (), [Mn(L)(N)(HO)]·1/3HO (), [Mn(L)(NCS)(HO)] (), and [Mn(L)(HO)](dca) () (where dca is dicyanamide ion). X-ray crystallography revealed that the Mn centers adopt a hexa-coordinate pseudo-octahedral geometry, where the equatorial plane is constructed with phenoxo oxygen and imine nitrogen atoms from the Schiff base ligand, while the axial positions are occupied by water molecules or a combination of water and pseudohalides.

View Article and Find Full Text PDF

Forty-eight stable structures of complexes formed between XCHZ and RCZOH (with X = H, F; R = H, F, Cl, Br, CH, NH; Z = O, S, Se, Te) were comprehensively investigated. It was found that the HZ-RZ complexes were more stable than the FZ-RZ ones, and their stability tendency decreased in the following order of Z: O > S > Se > Te. A predominant role of the electrostatic component was observed in XO-RO, while an outstanding contribution of the induction term was estimated in XS-RS, XSe-RSe, and XTe-RTe.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!