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Surgical Considerations in Tumor-Infiltrating Lymphocyte Therapy: Challenges and Opportunities.
Transplant Cell Ther
March 2025
Memorial Sloan Kettering Cancer Center, Department of Surgery, 1275 York Ave, New York, NY 10065.
Adoptive T cell therapy (ACT) using tumor-infiltrating lymphocytes (TILs) is a promising personalized immunotherapy approach, spearheaded by Dr. Steven Rosenberg, targeting various cancer types. Despite initial challenges in TIL production, recent advancements have showcased its superiority to immune checkpoint blockade in metastatic melanoma, even after anti-PD-1 therapy failure.
View Article and Find Full Text PDFHerbal-based Xuebijing injection ameliorated vascular endothelial dysfunction via inhibiting ACLY/MYB/RIG-I axis in sepsis-associated lung injury.
Phytomedicine
March 2025
Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, PR China. Electronic address:
Background: Excessive endothelial pro-inflammatory response is an early hallmark of sepsis-induced acute lung injury (ALI). Xuebijing (XBJ), a traditional Chinese medicine, is widely used in clinical practice to treat sepsis.
Purpose: This study aims to investigate the molecular mechanisms underlying the beneficial effects of XBJ.
Nimesulide: Critical Appraisal of Safety and Efficacy in Acute Pain.
J Assoc Physicians India
March 2025
President and Chief Medical Officer, Medical Division, Alkem Laboratories, Mumbai, Maharashtra, India.
Nimesulide, a potent nonsteroidal anti-inflammatory drug (NSAID), has garnered attention for its distinct mechanism of action, characterized by its selective inhibition of cyclooxygenase-2 (COX-2) and multifaceted pharmacological properties. Extensive clinical evidence supports its safety and efficacy in addressing acute pain syndromes. In this comprehensive review, we undertake a thorough examination of various dimensions surrounding nimesulide, encompassing its historical evolution, intricate mode of action, pharmacokinetic attributes, clinical efficacy in managing acute pain, and notably its safety profile.
View Article and Find Full Text PDFKidney and Lungs: Do they Cross-talk?
J Assoc Physicians India
March 2025
Professor, Department of Nephrology, Institute of Kidney Disease and Research Center, Ahmedabad, Gujarat, India.
The kidneys and lungs, often studied in isolation, are integral organs in maintaining homeostasis within the human body. However, the lung and kidney have multiple shared physiological and pathological pathways. It is important to understand these complex interactions and the cross-talk to manage patients, especially in critical care.
View Article and Find Full Text PDFPersistent Fourth Right Aortic Arch in a White-Tailed Deer (Odocoileus virginianus ustus).
Anat Histol Embryol
March 2025
Universidad San Francisco de Quito|Escuela de Medicina Veterinaria|Instituto de Biodiversidad Tropical|Hospital de Fauna Silvestre TUERI, Quito, Pichincha, Ecuador.
Persistent Fourth Right Aortic Arch (PRAA) with retention of the left ductus arteriosus constitutes the most prevalent clinically significant form of vascular ring anomalies in both dogs and cats, accounting for approximately 95% of aortic arch developmental anomalies. This anomaly causes oesophageal compression in weaned animals, leading to restricted passage of solid food, postprandial regurgitation, and potential development of acquired megaoesophagus. Notably, neonatal or lactating animals usually do not exhibit these consequences.
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