As a part of an ongoing project searching for new skin-lightening agents, the inhibitory property of 6-(3-Hydroxyphenyl)-2-naphthol (HPN) on melanogenesis was investigated. The inhibitory action of HPN (IC(50)=15.2 muM) on mushroom tyrosinase was revealed. To further explore the action of HPN on melanogenesis, the inhibition of tyrosinase and melanin levels were measured in B16 melanoma cells (B16 cells). Results show that HPN inhibited tyrosinase activity and reduced melanin in B16 cells. Therefore, our data indicate HPN as a new candidate for depigmentation reagents.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s12272-009-1235-9 | DOI Listing |
Publication Analysis
Top Keywords
tyrosinase activity
8
hpn melanogenesis
8
action hpn
8
b16 cells
8
hpn
5
inhibitory effects
4
effects 6-3-hydroxyphenyl-2-naphthol
4
tyrosinase
4
6-3-hydroxyphenyl-2-naphthol tyrosinase
4
activity melanin
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!