AI Article Synopsis
- HCV infection in dialysis patients with tunneled vascular catheters is linked to higher rates of bacteremia.
- A two-phase clinical study was conducted, with Phase 1 showing HCV(+) patients had a significantly greater prevalence of bacteremia compared to HCV(-) patients (61% vs 7.7%).
- Phase 2 indicated a trend of increased bacteremia incidence in patients with detectable HCV virus, suggesting a potential connection between HCV infection and bacteremia development.
Article Abstract
Background: The major complication of tunneled vascular catheters in dialysis patients is infection. In preliminary work, an association was noted between hepatitis C virus (HCV) infection and bacteremia in these patients. On this basis, we theorized that HCV infection may be associated with bacteremia in dialysis patients with tunneled catheters.
Methods: We conducted a two-phase clinical study to define the association between HCV infection and bacteremia in hemodialysis patients with catheters. Phase 1 was a cross-sectional study designed to assess the association between HCV serologic status and bacteremia. Phase 2 was a prospective study that examined the relationship between HCV viral load and bacteremia.
Results: In Phase 1, HCV (+) patients had a significantly greater prevalence of bacteremia than HCV (-) patients (61 vs 7.7% respectively, P < 0.05). In Phase 2, the presence of detectable virus was associated with a numerical trend toward an increase in the incidence of bacteremia (40 vs 0% for patients with and without detectable virus, respectively, P = 0.09).
Conclusion: These studies suggest that HCV infection may be associated with the development of bacteremia in hemodialysis patients with tunneled catheters.
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| http://dx.doi.org/10.1097/SMJ.0b013e31819bc34c | DOI Listing |
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