Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655610 | PMC |
| http://dx.doi.org/10.1128/MCB.00019-09 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Molecular Characterization of Cancer Preventive and Therapeutic Potential of Three Antistress Compounds, Triethylene Glycol, Withanone, and Withaferin A.
Int J Mol Sci
January 2025
AIST-INDIA DAILAB, National Institute of Advanced Industrial Science & Technology (AIST), Central 4-1, Tsukuba 305-8565, Japan.
The molecular link between stress and carcinogenesis and the positive outcomes of stress intervention in cancer therapy have recently been well documented. Cancer stem cells (CSCs) facilitate cancer malignancy, drug resistance, and relapse and, hence, have emerged as a new therapeutic target. Here, we aimed to investigate the effect of three previously described antistress compounds (triethylene glycol, TEG; Withanone, Wi-N, and Withaferin A, Wi-A) on the stemness and differentiation characteristics of cancer cells.
View Article and Find Full Text PDFCirculating, Extracellular Vesicle-Associated Tissue Factor in Cancer Patients with and without Venous Thromboembolism.
Biomolecules
January 2025
Dipartimento di Patologia Chirurgica, Medica, Molecolare e dell'Area Critica, University of Pisa, 56126 Pisa, Italy.
Cancer is characterized by chronic inflammation and hypercoagulability, with an excess of venous thromboembolism (VTE). Tissue factor, the initiator of blood coagulation, circulates associated with extracellular vesicles (EV-TF). Studies investigating EV-TF between cancer-associated and non-cancer-associated VTE are lacking.
View Article and Find Full Text PDFComprehensive Metabolomic Profiling in Adults with X-Linked Hypophosphatemia: A Case-Control Study.
Biomedicines
December 2024
Department of Nephrology, Hospital Universitari i Politècnic La Fe, 46026 Valencia, Spain.
Background: X-linked hypophosphatemia (XLH) is a rare disorder characterized by elevated levels of fibroblast growth factor 23 (FGF-23), leading to hypophosphatemia and complications in diagnosis due to its clinical heterogeneity. Metabolomic analysis, which examines metabolites as the final products of cellular processes, is a powerful tool for identifying in vivo biochemical changes, serving as biomarkers of pathological abnormalities, and revealing previously uncharted metabolic pathways.
Methods: A multicenter cross-sectional case-control study of adult patients diagnosed with XLH was conducted.
The Possible Crystallization Process in the Origin of Bacteria, Archaea, Viruses, and Mobile Elements.
Biology (Basel)
December 2024
Division of Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Japan.
We propose a hypothesis for the simultaneous emergence of bacteria, archaea, viruses, and mobile elements by sequential and concrete biochemical pathways. The emergence process can be considered analogous to crystallization, where genetic and biochemical systems stabilize as organisms evolve from their common ancestor, the LUCA, which was a non-free-living pool of single operon type genomes including double-stranded (ds) DNA at an ancient submarine alkaline vent. Each dsDNA operon was transcribed by different systems in σ, TFIIB, or TBP genomes.
View Article and Find Full Text PDFDeciphering the Neural Effects of Emotional, Motivational, and Cognitive Challenges on Inhibitory Control Processes.
Hum Brain Mapp
February 2025
Department of Psychological and Brain Sciences, University of Delaware, Newark, Delaware, USA.
Converging lines of research indicate that inhibitory control is likely to be compromised in contexts that place competing demands on emotional, motivational, and cognitive systems, potentially leading to damaging impulsive behavior. The objective of this study was to identify the neural impact of three challenging contexts that typically compromise self-regulation and weaken impulse control. Participants included 66 healthy adults (M/SD = 29.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!