AI Article Synopsis

  • The study explores the differences between sexes in schizophrenia, focusing on aspects like onset age and symptoms, but notes a lack of research on how these interact with general cognitive sex differences in healthy individuals.
  • Researchers tested 25 schizophrenia patients and 17 healthy controls on an object location memory task, where previous studies indicated that healthy females typically perform better than males.
  • The results confirmed the female advantage in healthy controls but revealed that this advantage does not exist among patients with schizophrenia, suggesting significant implications for understanding clinical and physiological sex differences in the disorder.

Article Abstract

Sex differences are pervasive in schizophrenia, ranging from differences in the age of onset and symptoms of the illness to structural brain differences. Yet, there has been very little research on the interaction of these differences with established cognitive sex differences that exist in healthy populations. We tested 25 patients with schizophrenia and 17 healthy controls on a two-dimensional task of object location memory. It has been previously shown that healthy females outperform healthy males on this task, a result that was upheld in this experiment. However, the female advantage is completely absent in patients with schizophrenia. This finding has important implications for the interpretation of clinical and physiological sex differences present in schizophrenia.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702996PMC
http://dx.doi.org/10.1016/j.psychres.2008.01.012DOI Listing

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