AI Article Synopsis
- Recent advancements in metabolomics have resulted in the identification of new metabolic biomarkers, but not all of them are immediately viable for clinical use.
- Distinguishing metabolites with varying levels between samples isn't enough to confirm their effectiveness as biomarkers; a thorough qualification process is essential.
- The overview evaluates the current landscape of metabolic biomarker discovery, pointing out both successes and challenges, while proposing methods for achieving clinical application.
Article Abstract
The current developments in metabolomics and metabolic profiling technologies have led to the discovery of several new metabolic biomarkers. Finding metabolites present in significantly different levels between sample sets, however, does not necessarily make these metabolites useful biomarkers. The route to valid and applicable biomarkers (biomarker qualification) is long and demands a significant amount of work. In this overview, we critically discuss the current state-of-the-art of metabolic biomarker discovery, with highlights and shortcomings, and suggest a pathway to clinical usefulness.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865640 | PMC |
| http://dx.doi.org/10.1007/s00216-009-2690-3 | DOI Listing |
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