Effects of carvedilol, losartan and trimetazidin on functional parameters of isolated heart of rats at oxidative stress.

Effects of carvedilol, lozartan and trimetazidin on functional parameters of isolated heart (heart rate and volume speed of coronary blood flow) of rats at oxidative stress have been studied with the use of Langendorf's method. Experiments have been carried out on 32 pubertal white rats (with body mass 220-250 g). Oxidative stress was induced through perfusion of hydrogen peroxide (with concentration - 4.10 -5 M). Obtained results were analyzed statistically according to the Student's t criterion. Studies have shown that carvedilol and trimetazidin have well expressed antioxidant and cardio protective effects at oxidative stress provoked by hydrogen peroxide compared to lozartan. Moreover, effect of carvedilol on HR and VsCBf was especially obvious than effects of Trimetazidin. Antioxidant and positive treatment effects of carvedilol could be explained by its wide range of pharmacological ability: as nonselective beta-adrenoblocker (via inhibition of adenylatecyclase and decreasing cyclic adenosinemonophosphate), alpha 1-adrenoblocker (decreasing activation of phospholipase C and concentration of inositoltriphosphate, diacylglicerole and Ca(++)) and antioxidant. It is suggested that positive effects of carvedilol on HR and VsCBf at oxidative stress are related with wide range of pharmacological mechanisms of preparation. Cardio protective effects of carvedilol at oxidative stress (revealed in our experiments) along with other positive cardio - hemodynamic peculiarities perhaps is very important and could be used successfully at treatment of cardio-vascular system diseases.