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Bioinformatics tools for screening of antiparasitic drugs. | LitMetric

Bioinformatics tools for screening of antiparasitic drugs.

Curr Drug Targets

Faculdade de Biociências, Laboratório de Bioquímica Estrutural, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil.

Published: March 2009

AI Article Synopsis

Article Abstract

Drug development has become the Holy Grail of many structural bioinformatics groups. The explosion of information about protein structures, ligand-binding affinity, parasite genome projects, and biological activity of millions of molecules opened the possibility to correlate this scattered information in order to generate reliable computational models to predict the likelihood of being able to modulate a target with a small-molecule drug. Computational methods have shown their potential in drug discovery and development allied with in vitro and in vivo methodologies. The present review discusses the main bioinformatics tools available for drug discovery and development.

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Source
http://dx.doi.org/10.2174/138945009787581122DOI Listing

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