Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/mpg.0b013e3181602190 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Survival Outcomes with Regorafenib and/or Trifluridine/Tipiracil Sequencing to Rechallenge with Third-Line Regimens in Metastatic Colorectal Cancer: A Multicenter Retrospective Real-World Subgroup Comparison from the ReTrITA Study.
Curr Oncol
December 2024
Oncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli-IRCCS, 00168 Rome, Italy.
Background: There is ongoing discussion around the optimal course of treatment for metastatic colorectal cancer (mCRC) following the second line. Trifluridine/tipiracil (T) and regorafenib (R) have been the mainstay of therapy in this situation, as they both increased overall survival (OS) in comparison to a placebo. Despite the paucity of evidence, therapy rechallenge is also recognized as an option for practical use.
View Article and Find Full Text PDFBackground And Objectives: The aim of this study was to externally validate the prognostic score for mechanically ventilated patients with novel coronavirus disease-2019 (COVID-19), the simplified intubated COVID-19 predictive (sICOP) score.
Methods: This was a retrospective, multicenter, observational study conducted using the database registry of patients with moderate-to-severe COVID-19 at 66 hospitals in Japan. The data of 146 mechanically ventilated COVID-19 patients were analyzed.
From SMILES to Enhanced Molecular Property Prediction: A Unified Multimodal Framework with Predicted 3D Conformers and Contrastive Learning Techniques.
J Chem Inf Model
December 2024
School of Mathematics and Statistics, Victoria University of Wellington, Kelburn Parade, Wellington 6012, New Zealand.
We present a novel molecular property prediction framework that requires only the SMILES format as input but is designed to be multimodal by incorporating predicted 3D conformer representations. Our model captures comprehensive molecular features by leveraging both the sequential character structure of SMILES and the three-dimensional spatial structure of conformers. The framework employs contrastive learning techniques, utilizing InfoNCE loss to align SMILES and conformer embeddings, along with task-specific loss functions, such as ConR for regression and SupCon for classification.
View Article and Find Full Text PDFImproving HIV testing, linkage, and retention in care among South African men through U = U messaging: A study protocol for two sequential hybrid type 1 effectiveness-implementation randomized controlled trials.
PLoS One
November 2024
Center for Health Incentives and Behavioral Economics, University of Pennsylvania, Philadelphia, PA, United States of America.
Background: Increasing HIV testing and treatment coverage among people living with HIV (PLHIV) is essential for achieving global HIV epidemic control. However, compared to women, cis-gender heterosexual men living with HIV are significantly less likely to know their HIV status, initiate anti-retroviral therapy (ART) and achieve viral suppression. This is particularly true in South Africa, where men are also at increased risk of mortality resulting from AIDS-related illnesses.
View Article and Find Full Text PDFMulti-omic characteristics of longitudinal immune profiling after breakthrough infections caused by Omicron BA.5 sublineages.
EBioMedicine
December 2024
CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, 100101, China. Electronic address:
Background: Omicron sub-variants breakthrough infections (BTIs) have led to millions of coronavirus disease 2019 (COVID-19) cases worldwide. The acute-phase immune status is critical for prognosis, however, the dynamic immune profiling of COVID-19 during the first month after BTIs remains unclear.
Methods: In this study, we monitored the immune dynamics at various timepoints in a longitudinal cohort during the first month post-BTIs through clinical evaluation, single-cell RNA sequencing (scRNA-seq), T cell receptor (TCR)/B cell receptor (BCR) sequencing, and antibody mass spectrometry.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!