Objective: It is an open question whether multifunctional galectin-3 can be a serum marker in inflammatory bowel disease.
Methods: Western blots and commercial ELISA detected and quantitated the lectin immunocytochemistry using double labeling localized it in tissue sections.
Results: Serum concentrations were significantly increased in specimen of patients with active and remission-stage ulcerative colitis and Crohn's disease, associated with emerging positivity of CD14(+) cells.
Conclusion: Enhanced concentration of galectin-3 in serum reflects presence of disease and points to its involvement in the pathogenesis.
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