AI Article Synopsis
- A new curcuminoid called 3'-demethoxycyclocurcumin was isolated from Curcuma xanthorrhiza and found to have antibabesial properties.
- Alongside it, compounds p-hydroxybenzaldehyde, cleomiscosin A, and (+)-epiloliolide were identified from Brucea javanica and Excoecaria cochinchinensis, respectively.
- The antibabesial activities of these compounds were tested in vitro, revealing IC(50) values of 16.6, 7.6, 15.6, and 10.0 microg/ml for compounds 1-4, compared to 0.6 microg/ml for the standard
Article Abstract
One new curcuminoid, 3'-demethoxycyclocurcumin (1), was isolated from Curcuma xanthorrhiza as an antibabesial compound, together with p-hydroxybenzaldehyde (2) and cleomiscosin A (3) from Brucea javanica and (+)-epiloliolide (4) from Excoecaria cochinchinensis. The antibabesial activities were examined in vitro, and compounds 1-4, and diminazene aceturate were studied with IC(50) values of 16.6, 7.6, 15.6, 10.0, and 0.6 microg/ml, respectively.
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| http://dx.doi.org/10.1271/bbb.80784 | DOI Listing |
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