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Clinical Manifestations.
Alzheimers Dement
December 2024
UT Health San Antonio, San Antonio, TX, USA.
Background: Motivational disturbances are a major harbinger for dementia, being associated with a two- to seven-fold higher conversion rate from mild cognitive impairment. However, there are currently no objective assessment methods for identifying motivational disturbances in older adults (OA). Here, we present preliminary findings from a larger study which aims to validate an objective behavioral measure of effort in OAs by investigating the effects of age, risk, and reward (gain vs.
View Article and Find Full Text PDFNovel inhibition of sortase A by plantamajoside: implications for controlling multidrug-resistant infections.
Appl Environ Microbiol
December 2024
Department of Gastrocolorectal Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China.
In confronting the significant challenge posed by multidrug-resistant (MDR) pathogens, particularly methicillin-resistant (MRSA), the development of innovative anti-infective strategies is essential. Our research focuses on sortase A (SrtA), a vital enzyme for anchoring surface proteins in . We discovered that plantamajoside (PMS), a phenylpropanoid glycoside extracted from .
View Article and Find Full Text PDFPrognostic Value of Strain by Speckle Tracking Echocardiography in Patients with Arrhythmogenic Right Ventricular Cardiomyopathy.
J Cardiovasc Dev Dis
December 2024
Institute of Cardiovascular Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Background Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare genetic disorder associated with an elevated risk of life-threatening arrhythmias and progressive ventricular impairment. Risk stratification is essential to prevent major adverse cardiac events (MACE). Our study aimed to investigate the incremental value of strain measured by two-dimensional speckle-tracking echocardiography in predicting MACE in ARVC patients compared to conventional echocardiographic parameters.
View Article and Find Full Text PDFTowards Point-of-Care Single Biomolecule Detection Using Next Generation Portable Nanoplasmonic Biosensors: A Review.
Biosensors (Basel)
December 2024
Department of Mechanical and Mechatronics Engineering, University of Waterloo, 200 University Ave. West, Waterloo, ON N2L 3G1, Canada.
Over the past few years, nanoplasmonic biosensors have gained widespread interest for early diagnosis of diseases thanks to their simple design, low detection limit down to the biomolecule level, high sensitivity to even small molecules, cost-effectiveness, and potential for miniaturization, to name but a few benefits. These intrinsic natures of the technology make it the perfect solution for compact and portable designs that combine sampling, analysis, and measurement into a miniaturized chip. This review summarizes applications, theoretical modeling, and research on portable nanoplasmonic biosensor designs.
View Article and Find Full Text PDFMonitoring and assessment of desertification reversal in ecologically fragile areas: A case study of the Mu Us Sandy Land.
J Environ Manage
December 2024
School of Geography and Tourism, Shaanxi Normal University, Xi'an, 710119, China.
Article Synopsis
- Desertification poses a significant challenge to sustainable development globally, but the Mu Us Sandy Land has successfully reversed it through effective national policies, showcasing positive ecological, economic, and social outcomes.
- Long-term monitoring data is currently lacking, making it hard to fully understand the ongoing dynamics and factors driving these changes; thus, there's an urgent need for quantitative assessments of ecological restoration efforts.
- Using Google Earth Engine and remote sensing data, this study produced a high-accuracy dataset showing a 69.45% decrease in desertification from 1986 to 2020 in the Mu Us Sandy Land, along with improvements in vegetation growth, demonstrating the effectiveness of restoration policies.
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