The initiation of DNA replication is a complex, multistep process with important implications for genomic stability. In this issue, Wu and Nurse (2009) find that initiation factors are differentially recruited to replication origins. They uncover evidence suggesting that the efficiency of this recruitment may determine whether and when an origin is used to initiate DNA replication in S phase.
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| http://dx.doi.org/10.1016/j.cell.2009.02.023 | DOI Listing |
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