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September 14, 2024 was the 100th anniversary of the birth of a major scientist, specialist in the field of medical climatology, clinical physiology of respiration and circulation, Honored Scientist of the Ukrainian SSR, Doctor of Medical Sciences, Professor Vyacheslav Georgievich Boksha (14.09.1924-22.

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Ultraviolet rays are known to have positive effect on psoriasis, but the cold climate and latitude in Northern Europe reduce access to the sun. Climatotherapy is a treatment modality where the patient is relocated to a warmer region with a high ultraviolet (UV) index. Young patients with psoriasis can be particularly burdened by the disease, and studies have shown an association between psoriasis and mood disorders.

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Secukinumab and Dead Sea treatment result in clear skin for many psoriasis patients, through distinct mechanisms. However, recurrence in the same areas after treatments suggests the existence of a molecular scar. We aimed to compare the molecular and genetic differences in psoriasis patients who achieved complete response from secukinumab and Dead Sea climatotherapy treatments.

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In our previous study setting, climatotherapy programme consisted of six sessions - four in the mid-mountain area and two in a flat park. For all sessions, the subjects underwent climatotherapy in the morning under slightly cool conditions. During each session, the subjects' blood pressure, pulse rate, skin temperature, blood lactate, salivary cortisol and mood profile were recorded, and meteorological data were collected at the sites.

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An accelerated climatotherapy programme was evaluated for use with busy people in mid-mountain and flat lowland areas. A total of 43 urban residents participated in this climatotherapy programme. Participants' blood pressure, pulse rate, peripheral skin temperature and levels of salivary amylase, salivary cortisol and blood lactate were measured, and they completed the Profile of Mood Status questionnaire.

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