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Real world delays in antivenom administration: patient, snake or hospital factors (ASP-33).
Clin Toxicol (Phila)
January 2025
Clinical Toxicology Research Group, University of Newcastle, Newcastle, Australia.
Objective: Early antivenom administration is essential for effective treatment. We investigated the delays in antivenom administration.
Methods: We reviewed snakebites from the Australian Snakebite Project (2006-2021) given antivenom, presenting to hospital within 12 h.
Chemical Reaction Simulator on Quantum Computers by First Quantization (II)─Basic Treatment: Implementation.
J Chem Theory Comput
November 2024
Institute of Industrial Science, The University of Tokyo, 4-6-1 Komaba, Meguro-ku, Tokyo 153-8505, Japan.
Chemical simulation is a key application area that can leverage the power of quantum computers. A chemical simulator that implements a grid-based first quantization method has promising characteristics, but an implementation fully in quantum circuits seems to have not been published. Here, we present "crsQ" (chemical reaction simulator Q), which is a quantum circuit generator that generates such a chemical simulator.
View Article and Find Full Text PDFIntraspecific venom variation in the medically important puff adder (Bitis arietans): Comparative venom gland transcriptomics, in vitro venom activity and immunological recognition by antivenom.
PLoS Negl Trop Dis
October 2024
Centre for Snakebite Research and Interventions, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
Background: Variation in snake venoms is well documented, both between and within species, with intraspecific venom variation often correlated with geographically distinct populations. The puff adder, Bitis arietans, is widely distributed across sub-Saharan Africa and into the Arabian Peninsula where it is considered a leading cause of the ~310,000 annual snakebites across the region, with its venom capable of causing substantial morbidity and mortality. Despite its medical importance and wide geographic distribution, there is little known about venom variation between different B.
View Article and Find Full Text PDFPro-inflammatory cytokines gene expression in liver and kidneys of rats exposed to a sub-lethal dose of Bitis arietans snake venom.
Cell Mol Biol (Noisy-le-grand)
October 2024
Department of Zoology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
Article Synopsis
- Bitis arietans, or the puff adder, has venom that causes significant pain and organ damage, and this study explores its effects on liver and kidney inflammation in rats.
- The research involved administering a controlled dose of BAV to rats and analyzing their blood and tissue samples over time to observe changes in inflammatory markers and organ function.
- Results indicated that a single low dose of BAV triggered acute inflammation in the liver and kidneys, with certain proinflammatory cytokines (like IL-1β, IL-6, and TNF-α) showing increased levels shortly after exposure, suggesting that higher doses could lead to more serious and lasting organ damage.
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