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Investigation of the locus near MC4R with childhood obesity in Americans of European and African ancestry. | LitMetric

AI Article Synopsis

  • A recent meta-analysis has shown a consistent link between obesity and the SNP rs17782313 near the MC4R gene in white populations, suggesting a genetic factor in obesity.
  • In a study involving 728 European-American obese children and 3,960 controls, certain SNPs showed a significant association with obesity, indicated by odds ratios close to 1.14.
  • However, this genetic association was not observed in African-American obese children, highlighting potential racial differences in the genetic risk factors for childhood obesity.

Article Abstract

Recently a modest, but consistently, replicated association was demonstrated between obesity and the single-nucleotide polymorphism (SNP), rs17782313, 3' of the MC4R locus as a consequence of a meta-analysis of genome-wide association (GWA) studies of the disease in white populations. We investigated the association in the context of the childhood form of the disease utilizing data from our ongoing GWA study in a cohort of 728 European-American (EA) obese children (BMI > or =95th percentile) and 3,960 EA controls (BMI <95th percentile), as well as 1,008 African-American (AA) obese children and 2,715 AA controls. rs571312, rs10871777, and rs476828 (perfect surrogates for rs17782313) yielded odds ratios in the EA cohort of 1.142 (P = 0.045), 1.137 (P = 0.054), and 1.145 (P = 0.042); however, there was no significant association with these SNPs in the AA cohort. When investigating all 30 SNPs present on the Illumina BeadChip at this locus, again there was no evidence for association in AA cases when correcting for the number of tests employed. As such, variants 3' to the MC4R locus present on the genotyping platform utilized confer a similar magnitude of risk of obesity in white children as to their adult white counterparts but this observation did not extend to AAs.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860794PMC
http://dx.doi.org/10.1038/oby.2009.53DOI Listing

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