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A Patient With Intracranial Multiple Meningiomas Combined With Neurofibromatosis type I.
J Craniofac Surg
January 2025
Department of Neurosurgery, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army.
The coexistence of intracranial multiple meningiomas and neurofibromatosis type 1 is a rare occurrence in the field of neurosurgery, presenting complex treatment challenges, unfavorable prognoses, and significant burdens on both families and society. Currently, the primary objective is to perform surgical total resection as far as possible, while considering postoperative adjuvant radiotherapy for cases where complete tumor resection is challenging. In this case, the patient has previously undergone multiple brain tumor resections and received radiation therapy.
View Article and Find Full Text PDFSUCLG1 promotes aerobic respiration and progression in plexiform neurofibroma.
Int J Oncol
February 2025
Department of Burn and Plastic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, P.R. China.
Plexiform neurofibromas (PNFs) are benign tumors that affect 20‑50% of patients with type I neurofibromatosis (NF1). PNF carries a risk of malignancy. There is no effective cure for PNF.
View Article and Find Full Text PDFTrigeminal Nerve Schwannoma: A Rare Case of Multisymptomatic Cranial Nerve Involvement.
Cureus
December 2024
Internal Medicine, Unidade Local de Saúde da Região de Aveiro, Aveiro, PRT.
Schwannomas (SCs) are benign tumors composed of neoplastic Schwann cells and are relatively uncommon intracranially. Although these tumors are frequently associated with neurofibromatosis type 2 (NF2), they may also arise idiopathically, and their pathogenesis remains poorly understood. A 70-year-old Caucasian man presented with a two-month history of vertigo, gait imbalance, and decreased visual acuity in the left eye accompanied by photophobia, nausea, vomiting, and occasional headaches.
View Article and Find Full Text PDFIntramedullary Schwannoma in the Cervical Region: A Case Report.
Cureus
November 2024
Neurosurgery, Erciyes University Faculty of Medicine, Kayseri, TUR.
Intramedullary schwannomas are a type of benign spinal cord tumor that originates from the Schwann cells of the nerve sheath. They are relatively rare and typically occur within the spinal cord itself, rather than in the surrounding tissue. Treatment options for cervical intramedullary schwannomas include surgical removal of the tumor, radiation therapy, and observation.
View Article and Find Full Text PDF[Expert consensus for full course management of plexiform neurofibroma (2025 edition)].
Zhonghua Yi Xue Za Zhi
December 2024
Neurofibromatosis type 1 (NF1) is an autosomal dominant genetic disorder caused by mutations in the NF1 gene, affecting approximately 1 in 3 000 newborns worldwide. Plexiform neurofibroma (PNF) is one of the common clinical manifestations of NF1. PNF can lead to a range of clinical symptoms, with a high rate of disability and teratogenesis; furthermore, there is a risk for malignant transformation that poses significant threats to the life and health of patients.
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