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Hydration of 3-Methyl-1,2,3-butanetricarboxylic Acid Evidenced by Matrix-Isolation Infrared Spectroscopy.
J Phys Chem A
January 2025
Institut des Sciences Moléculaires, UMR CNRS 5255, Univ. Bordeaux, Talence cedex F-33405, France.
The hydration mechanism of 3-methyl-1,2,3-butanetricarboxylic acid (MBTCA), a relevant marker of secondary organic aerosol formation from the atmospheric oxidation of α-pinene, has been investigated using the matrix-isolation infrared spectroscopy technique. The experimental results were supported by theoretical calculations. Monomers of MBTCA and heterocomplexes MBTCA-(HO) were identified.
View Article and Find Full Text PDFAnalysis of Drug Molecules in Living Cells.
Crit Rev Anal Chem
January 2025
Department of Bioengineering, Faculty of Engineering, The University of Edinburgh, Edinburgh, UK.
Cells are the fundamental units of life, comprising a highly concentrated and complex assembly of biomolecules that interact dynamic ally across spatial and temporal scales. Living cells are constantly undergoing dynamic processes, therefore, to understand the interactions between drug molecules and living cells is of paramount importance in the biomedical sciences and pharmaceutical development. Compared with traditional end-point assays and fixed cell analysis, analysis of drug molecules in living cells can provide more insight into the effects of drugs on cells in real-time and allowing for a better understanding of drug mechanisms and effects, which will contribute to the development of drug developing and testing and personalize medicine.
View Article and Find Full Text PDFCrystallisation Based Deracemisation and Chiral Resolution of Small Molecules.
Chem Asian J
January 2025
Mahatma Gandhi University, School of Chemical Sciences, Priyadarsini Hills, 686560, Kottayam, INDIA.
Enantiomeric separation of chiral molecules is pivotal for exploring fundamental questions about life's origin and many other fields. Crystallisation is an important platform for the separation of chiral molecules, elegantly applied to many systems, for instance, the formation of conglomerates, where the enantiomers crystallise as separate phases. Many approaches have been proposed to explore crystallisation-driven enantiomeric separation with fewer insights into the complex pathways associated with the separation processes.
View Article and Find Full Text PDFHybrid Quality-Based Recommender Systems: A Systematic Literature Review.
J Imaging
January 2025
Laboratory Health Systemic Process (P2S), UR4129, University Claude Bernard Lyon 1, University of Lyon, 69008 Lyon, France.
As technology develops, consumer behavior and how people search for what they want are constantly evolving. Online shopping has fundamentally changed the e-commerce industry. Although there are more products available than ever before, only a small portion of them are noticed; as a result, a few items gain disproportionate attention.
View Article and Find Full Text PDFMetabolic profiling of meningioma reveals novel subgroup-specific biologic insights and outcome dependencies.
Neuro Oncol
January 2025
MacFeeters Hamilton Neuro-Oncology Program, Princess Margaret Cancer Centre, University Health Network and University of Toronto, Toronto, ON, Canada.
Background: Our group and others have recently identified four molecular groups of meningioma, with unique underlying biology and outcomes. The relevance of group-specific metabolite profiles (particularly among hypermetabolic tumours), has not been explored.
Methods: We performed untargeted metabolic profiling of meningiomas representing each molecular group and WHO grade.
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