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Photoprotective effect of Pothomorphe umbellata on UVB radiation-induced biomarkers involved in carcinogenesis of hairless mouse epidermis. | LitMetric

AI Article Synopsis

  • This study investigated the effects of Pothomorphe umbellata extract on skin damage caused by UVB radiation in hairless mice.
  • Results showed that UVB exposure decreased thymine dimer-positive and apoptotic cells, while increasing p53 and proliferating cell nuclear antigen-positive cells.
  • After prolonged UVB exposure, treatment with P. umbellata led to reduced skin hyperplasia and an increase in protective p53-positive cells, indicating its potential to protect against UVB-induced skin damage.

Article Abstract

In this study we assessed the protective effect of topical application of Pothomorphe umbellata extract on ultraviolet B (UVB)-induced skin lesion parameters in hairless mouse epidermis. A single dose of UVB irradiation (0.23 kJ/m2) resulted in a significant decrease in thymine dimer-positive cells and apoptotic sunburn cells, with an increase in p53 and proliferating cell nuclear antigen-positive cells in the epidermis. After 5 weeks (total dose 13.17 kJ/m2) and 15 weeks (total dose 55.51 kJ/m2) of irradiation, P. umbellata treatment inhibited the hyperplasic response and induced an increase in p53-positive cells. These findings suggest that P. umbellata extract affords protection against UVB-induced skin lesions.

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Source
http://dx.doi.org/10.1080/15569520902784014DOI Listing

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