Aim: To study the association between genetic variants in myocilin and collagen type I alpha 1 genes and high myopia in an isolated island population.
Methods: A total of 944 examinees from the genetic epidemiology study conducted on the island of Korcula, Croatia, were included in the study. We selected 2 short nucleotide polymorphisms (SNP) available in our genome-wide scan set of SNPs that were previously associated with high myopia and used them to replicate previous claims of possible association.
Results: Nineteen cases of high myopia, defined as the refraction of
Conclusion: Myocilin seems to be a very strong candidate for explaining some of the pathophysiological pathways leading to the development of both glaucoma and high myopia. As our finding was obtained in a relatively under-powered sample, further research and replication of these results is needed.
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| http://dx.doi.org/10.3325/cmj.2009.50.17 | DOI Listing |
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