Background: We investigated the incremental diagnostic value of short tau inversion recovery (STIR) MRI to detect cervical nodal metastases in head and neck squamous cell carcinoma.
Methods: Thirty-six patients with cervical nodal metastases underwent MRI preceding neck dissection. Two readers evaluated MRI versus MRI with STIR. Level-based analysis was performed: interobserver agreements (kappa) for detecting normal and metastatic lymph nodes; sensitivities and specificities for detecting at least 1 metastatic lymph node per level; linear regression analysis to determine performances of MRI with STIR in detecting correct numbers of normal and metastatic lymph nodes. Histopathology was the reference standard.
Results: One hundred eighty neck levels were evaluated. MRI with STIR showed better kappas for metastatic and normal lymph nodes, was more accurate to estimate numbers of metastatic and normal lymph nodes, and showed improvement of sensitivities and specificities.
Conclusion: Incorporation of STIR into the conventional MR protocol significantly improves the detection of cervical lymph node metastases.
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http://dx.doi.org/10.1002/hed.21060 | DOI Listing |
J Ultrasound Med
January 2025
Department of Radiodiagnosis, Government Medical College and Hospital, Chandigarh, India.
Objectives: To determine the efficacy of quantitative shear wave elastography in differentiating benign and malignant axillary lymph nodes (ALN).
Methods: Exactly 127 lymph nodes from 127 patients with clinically palpable axillary swelling were examined by both B-mode sonography and elastography from November 2022 to March 2024. Gray-scale sonograms were evaluated based on: the short-axis diameter, shape, hilum, maximum cortical thickness, and border of the ALN.
Pheochromocytoma (PHEO) currently is considered to be malignant due to metastatic potential. One of the most common familial forms of PHEO is multiple endocrine neoplasia syndrome (MEN) type 2. The penetrance of PHEO in MEN2 syndrome is up to 50% of cases.
View Article and Find Full Text PDFFront Oncol
January 2025
Department of Urology, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Background: Penile metastasis originating from prostate cancer is an extremely rare condition, typically associated with a poor prognosis. Therapeutic approaches are not well established and may require individualized adaptation based on clinical assessment. Radiotherapy is commonly utilized to alleviate symptoms.
View Article and Find Full Text PDFFront Oncol
January 2025
Departments of Ultrasound, Jiading District Central Hospital Affiliated Shanghai University of Medicine &Health Sciences, Shanghai, China.
Background: Skip lymph node metastasis (SLNM) in papillary thyroid cancer (PTC) involves cancer cells bypassing central nodes to directly metastasize to lateral nodes, often undetected by standard preoperative ultrasonography. Although multiple models exist to identify SLNM, they are inadequate for clinically node-negative (cN0) patients, resulting in underestimated metastatic risks and compromised treatment effectiveness. Our study aims to develop and validate a machine learning (ML) model that combines elastography radiomics with clinicopathological data to predict pre-surgical SLNM risk in cN0 PTC patients with increased risk of lymph node metastasis (LNM), improving their treatment strategies.
View Article and Find Full Text PDFBioact Mater
April 2025
School of Life Sciences and Health Engineering, Jiangnan University, Wuxi, 214122, PR China.
Peptide vaccines based on tumor antigens face the challenges of rapid clearance of peptides, low immunogenicity, and immune suppressive tumor microenvironment. However, the traditional solution mainly uses exogenous substances as adjuvants or carriers to enhance innate immune responses, but excessive inflammation can damage adaptive immunity. In the current study, we propose a straightforward novel nanovaccine strategy by employing homologous human ferritin light chain for minimized innate immunity and dendritic cell (DC) targeting, the cationic KALA peptide for enhanced cellular uptake, and suppressor of cytokine signaling 1 (SOCS1) siRNA for modulating DC activity.
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