AI Article Synopsis
- The study aimed to assess the prevalence of transient hyperglycemia (TH) in pediatric patients with acute lymphoblastic leukemia (ALL) and analyze how various factors, such as medication type and patient demographics, affect TH occurrence.
- A retrospective review of records from 162 patients diagnosed with ALL revealed that 20.4% experienced TH, with prevalence significantly higher in those over age 10 and among overweight individuals.
- The findings indicate that native L-asparaginase was linked to increased TH rates, making age, weight, and the type of asparaginase important predictors of TH in this population.
Article Abstract
Background: Transient hyperglycemia (TH) is a recognized side effect of the corticosteroids and asparaginase given during induction chemotherapy for pediatric acute lymphoblastic leukemia (ALL). Information is needed about how TH has been impacted by changes in ALL therapy. This study examined the prevalence of TH in a cohort of pediatric ALL patients and the impact on TH of type of steroid or asparaginase used and of risk factors such as age, gender, and overweight.
Methods: Retrospective record review of patients aged 2-18 years diagnosed with ALL in 1999-2006. TH was defined as >or=2 random glucose values >or=200 mg/dl. Overall prevalence of TH was calculated. Risk factors were evaluated using Chi-square analysis and logistic regression.
Results: One hundred sixty-two subjects (70 female) were reviewed, 33 (20.4%) of whom had TH. 42.2% of subjects over age 10 years had TH, compared to 12.0% of younger children (P < 0.001). No gender difference was found. Overweight (BMI >or= 95th percentile) and at risk for overweight (BMI >or= 85th percentile) were significant risk factors for TH (P = 0.007 and P = 0.003, respectively). Native L-asparaginase was associated with increased TH compared to PEG-asparaginase (P = 0.047). There was a non-significant trend toward more TH in patients who received prednisone, but this disappeared in multivariate analysis.
Conclusions: The prevalence of TH in this study was higher than previously reported. Overweight, age >or=10 years, and use of native L-asparaginase were significant predictors of TH.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pbc.21980 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Predictive value of early pregnancy uric acid levels for adverse pregnancy outcomes.
Afr J Reprod Health
December 2024
Department of Obstetrics, Xiaolan People's Hospital of Zhongshan (The Fifth People's Hospital of Zhongshan), Zhongshan,528415, China.
Elevated serum uric acid (SUA) levels in pregnancy are linked to adverse outcomes, including preterm birth, preeclampsia, and low birth weight. To assess the predictive value of SUA levels in early pregnancy for adverse pregnancy outcomes (APOs). A cohort of 4,240 pregnant women admitted for delivery from January 2021 to December 2022 was analyzed.
View Article and Find Full Text PDFPrevalence and incidence of HPV-related dysplasia of oropharyngeal, cervical, and anal mucosae in Spanish people living with HIV (PLHIV).
AIDS
January 2025
Internal Medicine Department, Hospital Universitario Virgen de las Nieves, Instituto de Investigación Biosanitario de Granada (IBS-Granada), Spain.
Background: Objectives were to determine the prevalence/incidence of HPV-related dysplasia and clearance/acquisition rates of high-risk HPV (HR-HPV) genotypes in genital mucosa of women-LHIV and oropharyngeal and anal mucosa of PLHIV and to evaluate factors related to HR-HPV infection in oropharyngeal mucosa at 12-months.
Material And Methods: Prospective, longitudinal study with 12-month follow-up, enrolled PLHIV between December 2022 and April 2023. At baseline and 12-months, HIV-related clinical and analytical variables were recorded, oropharyngeal mucosa exudates were taken for polymerase chain reaction (PCR) studies for HPV and other sexually transmitted infections, while anal and female genital samples were self-sampled for HPV detection and genotyping by PCR and thin-layer cytology.
Exploring food safety knowledge and practices in Lebanon.
East Mediterr Health J
December 2024
Institut National de Santé Publique, d'Épidémiologie Clinique et de Toxicologie-Liban, Beirut, Lebanon.
Background: Lebanon's economic and financial crises have affected the quality-of-life, including food safety and food security.
Aim: To assess food safety knowledge and practices among a sample Lebanese population and the association with the sociodemographic and economic characteristics of participants.
Methods: This cross-sectional study collected data online from 412 Lebanese adults aged ≥ 18 years [mostly female (77.
No evidence that breast cancer occurs at higher rates among young Arab women.
East Mediterr Health J
December 2024
Department of Radiology, King Abdulaziz University, Jeddah, Saudi Arabia.
Article Synopsis
- The study investigates breast cancer incidence rates among Arab women compared to women from high- and middle-income countries, focusing on age-specific data.
- Findings reveal that young Arab women have breast cancer rates that are comparable to or lower than those in selected high- and middle-income countries, contradicting the perception of higher risk in this demographic.
- The results suggest that the higher number of cases in Arab countries may be attributed to a younger population structure, emphasizing the need for updated breast cancer screening policies in the region.
Typical Atrial Flutter: A Practical Review.
J Cardiovasc Electrophysiol
January 2025
Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.
Typical atrial flutter (AFL), defined as cavotricuspid isthmus (CTI)-dependent macro-re-entrant atrial tachycardia, often causes debilitating symptoms, and is associated with increased incidence of atrial fibrillation, stroke, heart failure, and death. Typical AFL occurs in patients with atrial remodeling and shares risk factors with atrial fibrillation. It is also common in patients with a history of prior heart surgery or catheter ablation.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!