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Fragment-to-Lead Medicinal Chemistry Publications in 2023.
J Med Chem
January 2025
Astex Pharmaceuticals, 436 Cambridge Science Park, Milton Road, Cambridge CB4 0QA, United Kingdom.
This Perspective summarizes successful fragment-to-lead (F2L) studies that were published in 2023 and is the ninth installment in an annual series. A tabulated summary of the relevant articles published in 2023 is provided (17 entries from 16 articles), and a comparison of the target classes, screening methods, and overall fragment or lead property trends for 2023 examples and for the combined entries over the years 2015-2023 is discussed. In addition, we identify several trends and innovations in the 2023 literature that promise to further increase the success of fragment-based drug discovery (FBDD), particularly in the areas of NMR and virtual screening, fragment library design, and fragment linking.
View Article and Find Full Text PDFCharacteristics of Peripheral Intravenous Catheter Cannulation in Older Japanese Inpatients.
J Infus Nurs
December 2024
Author Affiliations: Faculty of Nursing, Department of Nursing, Josai International University, Chiba, Japan (Mss Kitada and Tateno; Drs Ninomiya and Kabashim); Faculty of Pharmaceutical Sciences, Department of Medical Pharmacy, Josai International University, Chiba, Japan (Dr Yamamura); Behavioral Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan (Dr Hori).
Age-related physiological changes affect various aspects of peripheral intravenous catheter (PIVC) cannulation. However, the characteristics of PIVCs, especially in older patients, have been poorly investigated. In the current cross-sectional observational study, PIVC sizes, PIVC sites, the number of attempts until successful insertion, and the degree of venodilation upon insertion among hospital inpatients aged ≥65 years were investigated, along with measurements of the vessel diameter and depth using ultrasound.
View Article and Find Full Text PDFSurgical Obliteration of a Filum Terminale Arteriovenous Fistula Following Aborted Endovascular Embolization: Illustrative Case Report and Literature Review.
Cureus
December 2024
Department of Neurological Surgery, Rutgers University New Jersey Medical School, Newark, USA.
Arteriovenous fistulas of the filum terminale are rare vascular malformations that predominantly affect males and can present with various neurological symptoms. In this study, we indexed previously published cases of filum terminale arteriovenous fistulas demonstrating that endovascular and microsurgical management are both proven to be appropriate and successful treatment modalities with low complication rates. Endovascular treatment is far less invasive; however, it is associated with higher failure rates, which need to be managed surgically.
View Article and Find Full Text PDFDeterminants of quality of life following resection of skull base tumors: a systematic review.
Front Oncol
December 2024
Department of Neurosurgery and Neurorestoration, Klinikum Klagenfurt am Wörthersee, Klagenfurt, Austria.
Background: Skull base tumors represent a small subset of intracranial neoplasm. Due to their proximity to critical neurovascular structures, their resection often leads to morbidity. As a result, surgical interventions can exacerbate symptoms or cause new deficits, thereby impacting the patients' perceived quality of life (QoL).
View Article and Find Full Text PDFSlovenian Journal of Public Health: The Journey so Far and the Road Ahead.
Zdr Varst
March 2025
National Institute of Public Health, Trubarjeva cesta 2, 1000 Ljubljana, Slovenia.
The Slovenian Journal of Public Health, established 63 years ago as the official publication of the National Institute of Public Health in Slovenia, was initially aimed at tracking the development of public health in Slovenia and disseminating scientific advancements to professionals in the field. In 2000, a new editorial board took over and shifted the journal's focus towards enhancing scientific rigour and achieving international recognition. This strategic transformation led to the journal being indexed in the Social Sciences Citation Index (SSCI) in 2009, specifically within the category of Public, Environmental & Occupational Health.
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