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http://dx.doi.org/10.1103/PhysRevLett.102.029701 | DOI Listing |
Eur Respir J
January 2025
Neonatal Intensive Care Unit, Department of Pediatrics, University Hospital of Patras, Patras, Greece.
Drugs
December 2024
Springer Nature, Private Bag 65901, Mairangi Bay, Auckland, 0754, New Zealand.
Arimoclomol (MIPLYFFA™), an oral small molecule that crosses the blood brain barrier and is thought to upregulate CLEAR (Coordinated Lysosomal Expression and Regulation) network genes and improve lysosomal function, is being developed by Zevra Therapeutics Inc., for the treatment of neurological manifestations of Niemann-Pick disease type C (NPC). In September 2024, arimoclomol was approved for use in combination with miglustat for the treatment of neurological manifestations of NPC in adult and pediatric patients 2 years of age and older in the USA.
View Article and Find Full Text PDFHypertens Res
December 2024
Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan.
The synergistic interplay between cortisol and aldosterone is critical for maintaining homeostasis, particularly in blood pressure regulation, fluid balance, and stress response. Cortisol, a glucocorticoid, and aldosterone, a mineralocorticoid, often act in tandem to regulate sodium retention and blood volume. Dysregulation of these hormones, as seen in hyperaldosteronism or Cushing's syndrome, contributes to hypertension and metabolic imbalances.
View Article and Find Full Text PDFRheumatology (Oxford)
December 2024
Department of Pathology, University of California San Diego, La Jolla, CA, USA.
Science
December 2024
Sainsbury Lab, University of East Anglia, Colney Lane, Norwich, UK.
Small molecules activate a defense mechanism shared by all flowering plants.
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