AI Article Synopsis
- The study examined reflux events in patients with persistent laryngeal symptoms who didn't respond to proton pump inhibitor (PPI) treatment.
- Researchers reviewed the records of 21 patients with throat issues and compared them to 30 patients with typical reflux symptoms.
- Findings showed that while 24% of throat patients had normal reflux levels, 62% had abnormal acid reflux, indicating that many still suffer from reflux issues despite taking PPIs.
Article Abstract
Purpose: The aim of this study was to characterize the reflux events in patients with laryngeal symptoms unresponsive to proton pump inhibitor (PPI) therapy.
Background: Gastroesophageal reflux disease (GERD) is commonly implicated as the cause of laryngeal symptoms.
Methods: We retrospectively reviewed the pH/impedance records of 21 patients evaluated for persistent throat symptoms despite PPI therapy. They were compared to 30 others with typical reflux symptoms despite medication.
Results: Five of 21 (24%) patients in the "throat group" had normal reflux values, 13 (62%) continued to have abnormal acid reflux, and three (14%) had abnormal nonacid reflux but normal acid reflux while on medication. These results did not differ from those with typical symptoms unresponsive to medication.
Conclusion: In patients with chronic laryngeal symptoms despite PPI therapy, a substantial minority have no reflux at all, but the majority have abnormal amounts of acid reflux despite their taking PPI medication.
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| http://dx.doi.org/10.1007/s10620-009-0752-1 | DOI Listing |
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