AI Article Synopsis

  • * Findings showed that the R allele of the ERb gene was more common in the control group, suggesting it may protect against HCC, while the A allele was more prevalent in HCC patients, indicating it could be a risk factor for the disease.
  • * Overall, the research concluded that variations in the ERb gene are associated with primary liver cancer, highlighting the potential roles of different alleles in cancer risk.

Article Abstract

Objective: To investigate whether there is a association between estrogen receptor beta (ERb) gene polymorphism and primary hepatocellular carcinoma (HCC).

Methods: 100 primary HCC patients and 100 controls from southwestern China were recruited in this study. The polymorphism of RsaI and AluI in ERb gene was analyzed by PCR- restriction fragment length polymorphism (RFLP).

Results: R allelic frequency was 35.0% and 51.0% in HCC patients and in control group, respectively, odds ratio (OR) was 0.517 [95% confidence intervals (CI) = 0.346-0.773], P less than 0.01. A allelic frequency was 20.5% and 11.0% in HCC patients and in control group, respectively, OR was 2.086 (95% CI = 1.191-3.654), P less than 0.01. Gene frequency of RsaI and AluI in the two groups was distributed with polymorphism.

Conclusion: ERb gene polymorphism is associated with primary liver cancer. R allele may be the guard factor, and A allele may be its risk factor.

Download full-text PDF

Source

Publication Analysis

Top Keywords

rsai alui
12
erb gene
12
hcc patients
12
estrogen receptor
8
receptor beta
8
primary hepatocellular
8
gene polymorphism
8
allelic frequency
8
patients control
8
control group
8

Similar Publications

Objective This study aimed to investigate follicle-stimulating hormone receptor (FSHR) polymorphisms (Thr307Ala and Asn680Ser), estrogen receptor 1 (ESR1) polymorphisms (PvuII and XbaI), and ESR2 polymorphisms (RsaI and AluI) in Turkish women with follicle-stimulating hormone (FSH) and anti-Mullerian hormone (AMH) discordance. Method Genotyping was performed in 60 patients aged 21-35 with FSH-AMH discordance and/or low ovarian reserve and 20 age-matched controls with normal FSH and AMH levels. The patients were investigated in four groups of 20 women according to their FSH and AMH levels.

View Article and Find Full Text PDF

Purpose: Estrogen receptor (ER) genes play key roles in male and female reproduction. Non-obstructive azoospermia (NOA) and severe secretory oligozoospermia (SOL) are the most severe and complex conditions impacting male fertility. This meta-analysis aimed to study the association between PvuII ( rs2234693, 397T>C ), XbaI ( rs9340799, 351G>A ), AluI (1730G>A, rs4986938), and RsaI (1082G>A, rs1256049) polymorphisms and spermatogenic failure.

View Article and Find Full Text PDF

This study aimed to investigate the impact of single-nucleotide polymorphisms (SNPs) on milk production traits in Kilis dairy goats by analyzing the genotypes of , , , , and genes and their association with lactation milk yield (LMY), lactation length (LL) and average daily milk yield (ADMY). Blood samples were collected from 227 goats, and genotyping was performed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The results revealed that the frequencies of the genotypes varied among the genes.

View Article and Find Full Text PDF

Background: Gene polymorphisms of estrogen receptor (ESR) 1 PvuII (rs2234693), XbaI (rs9340799), G2014A (rs2228480), ESR2 AluI (rs4986938), and RsaI (rs1256049) had been reported to be associated with the risk of osteoporosis. However, these conclusions were inconsistent, therefore, an updated meta-analysis was conducted to further explore these issues.

Objective: To evaluate the association between gene polymorphisms of ESR1 PvuII (rs2234693), XbaI (rs9340799), G2014A (rs2228480), ESR2 AluI (rs4986938), RsaI (rs1256049), and osteoporosis risk.

View Article and Find Full Text PDF

First Report of 16SrII Group Related Phytoplasma Associated with Areca Palm Yellow Leaf Disease on Areca catechu in China.

Plant Dis

July 2023

Chinese Academy of Tropical Agricultural Sciences, 117453, coconut research institute, number 496 of Wenqing road, Wenchang, Hainan, Haikou, China, 571101;

Article Synopsis
  • * In 2020, YLD affected over 32,000 hectares in Hainan, leading to yield losses of 50% to 60%. Recent studies indicate the disease is caused by specific phytoplasma strains.
  • * Research conducted in 2022 analyzed symptomatic and asymptomatic plants from Wenchang, using DNA extraction and nested PCR methods to identify YLD-causing phytoplasmas, finding that four out of forty symptomatic samples contained
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!