Aim: Detection and analysis of similarities and differences in patients with family and polygenic hypercholesterolemia (FHCE and PHCE).
Material And Methods: The study included 100 patients with FHCE and 80 PHCE patients with LD-LP cholesterol level at least 4.3 mmol/l (170 mg/dl).
Results: The patients differed by age, gender, severity of hypercholesterolemia, clinical symptoms. Half of PHCE patients had myocardial infarction, 18% had angina pectoris, 29% cerebrovascular events. The disease was asymptomatic in 19% FHCE patients, 33% had myocardial infarction, 15%--angina pectoris, 12%--cerebrovascular events, 9%--aortic problems. Total mortality in both groups was similar--32 and 33%. Long-term treatment with statins reduced lethality twice both in FHCE and PHCE. Adequate statin therapy prolonged life of the patients by 11 years, on the average.
Conclusion: Regular treatment of patients with hypercholesterolemia reduces lethality and prolong their life span.
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