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Background: Understanding the genetic etiology of Alzheimer's disease (AD) has been a major focus of research in neurodegenerative diseases. Amid the three common allelic variants of the apolipoprotein E (APOE) gene in humans, called APOE ε2, ε3 and ε4, the ε4 allele is the most common genetic risk factor for late-onset AD, being found in 20% of the world population.
Method: We used Event-Related Potentials (ERP) and Event-Related Spectral Perturbation (ERSP) as features for classification of apolipoprotein E ϵ4 (APOE ε4) allele carriers in AD patients and healthy controls.
Biomarkers.
Alzheimers Dement
December 2024
Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy.
Background: Alzheimer's disease dementia (ADD) is the most common neurodegenerative dementing disorder, explaining about 60-70% of 50 million patients worldwide (www.who.int).
View Article and Find Full Text PDFBackground: Attention deficits are notable in Lewy body dementia (LBD) and in Alzheimer's disease (AD), however, its underlying neurobiology and neuropathology are unclear. Functional magnetic resonance imaging (fMRI) and electroencephalograph (EEG) provides information about attention deployment and regional neural oscillatory deficits in LBD and AD. In this study, we combined fMRI and EEG to detect neural correlates of attention dysfunctions in LBD and AD.
View Article and Find Full Text PDFBackground: Chronic pain remains mostly untreated in those with Alzheimer's disease and related dementias (ADRD), mainly due to limited capacity to verbalize pain. Development of reliable objective biomarkers of chronic pain could improve pain assessment and treatment. We explored feasibility and acceptability of using a wearable electroencephalograph (EEG) and a screen-based eye tracker system to identify neural signatures of chronic pain in this population.
View Article and Find Full Text PDFBackground: Postoperative delirium (POD) is characterized by fluctuating attention after surgery and is associated with increased risk of developing Alzheimer's Disease (AD). While the neurophysiological changes that underlie POD and increased risk of AD are unclear, recent data has raised the possibility that an exaggerated brain response to anesthetics may be a biomarker for POD risk and preclinical AD-like pathology. Thus, we examined whether anesthetic-dose-adjusted intraoperative brain activity is associated with POD or preoperative brain vulnerabilities (preclinical AD-like pathology, preoperative inattention) that may contribute to risk of POD (and later AD).
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