AI Article Synopsis
- Down syndrome (DS) is the leading cause of mental retardation, with immunological changes noted since the 1970s.
- The neurological system in individuals with DS seems to age faster, even showing signs of Alzheimer’s disease earlier than usual.
- Current research suggests that the immune system in DS patients may be inherently deficient from the start, rather than just a consequence of aging.
Article Abstract
Down syndrome (DS) is the most frequent cause of mental retardation in man. Immunological changes in DS have been observed since the 1970s. The neurological system appears to be ageing precociously, with early occurrence of Alzheimer disease; until now, the observed immunological differences have been interpreted in the same context. Looking back at past and present results of immunological studies in DS children in relation to the clinical consequences they suffer, we conclude that it is more likely that the DS immune system is intrinsically deficient from the very beginning.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2759463 | PMC |
| http://dx.doi.org/10.1111/j.1365-2249.2009.03890.x | DOI Listing |
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