AI Article Synopsis
- Sulfamides show potential for creating new antiepileptic drugs, as detailed in a 2007 study.
- Researchers designed and synthesized sulfamides derived from amino acids to evaluate their anticonvulsant properties.
- Some tested compounds effectively reduced convulsions in the MES test at low doses (100 mg/kg).
Article Abstract
Sulfamides are promising functions for the design of new antiepileptic drugs ( Bioorg. Med. Chem. 2007, 15, 1556-1567; 5604-5614 ). Following previous research in this line, a set of amino acid-derived sulfamides has been designed, synthesized, and tested as new anticonvulsant compounds. The experimental data confirmed the ability of some of the structures to suppress the convulsions originated by the electrical seizure (MES test) at low doses (100 mg/kg).
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| http://dx.doi.org/10.1021/jm800764p | DOI Listing |
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